ArticleBMC cancer2007
Reduction of peritoneal carcinomatosis by intraperitoneal administration of phospholipids in rats.
Article in BMC cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- CD31 and D2-40 Contribute to Peritoneal Metastasis of Colorectal Cancer by Promoting Epithelial-Mesenchymal Transition.Gut and liver · 2021Article
- EPAS1 promotes peritoneal carcinomatosis of non-small-cell lung cancer by enhancing mesothelial-mesenchymal transition.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021Article
- Apatinib Mesylate Inhibits the Proliferation and Metastasis of Epithelioid Malignant Peritoneal MesotheliomaFrontiers in oncology · 2020Article
- Article
- Specific computed virtual chromoendoscopy for detection of peritoneal carcinomatosis: an animal study.Surgical endoscopy · 2017Article
- Animal models of colorectal peritoneal metastasis.Pleura and peritoneum · 2016Review
- The parity-associated microenvironmental niche in the omental fat band is refractory to ovarian cancer metastasis.Cancer prevention research (Philadelphia, Pa.) · 2013Article
- Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of gastric cancer with peritoneal carcinomatosis: evidence from an experimental study.Journal of translational medicine · 2011Article
- Netrin-4 delays colorectal cancer carcinomatosis by inhibiting tumor angiogenesis.The American journal of pathology · 2011Article
- Establishment and identification of a rabbit model of peritoneal carcinomatosis from gastric cancer.BMC cancer · 2010Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntraperitoneal tumor cell attachment after resection of gastrointestinal cancer may lead to a developing of peritoneal carcinosis. Intraabdominal application of phospholipids shows a significant decrease of adhesion formation even in case of rising tumor cell concentration.
methodsIn experiment A 2*106 colonic tumor cells (DHD/K12/Trb) were injected intraperitonely in female BD-IX-rats. A total of 30 rats were divided into three groups with treatments of phospholipids at 6% or 9% and the control group. In experiment B a total of 100 rats were divided into ten groups with treatments of phospholipids at 9% and the control group. A rising concentration of tumor cells (10,000, 50,000, 100,000, 250,000 and 500,000) were injected intraperitonely in female BD-IX-rats of the different groups. After 30 days, the extent of peritoneal carcinosis was determined by measuring the tumor volume, the area of attachment and the Peritoneal Cancer Index (PCI).
resultsIn experiment A, we found a significant reduction (control group: tumor volume: 12.0 +/- 4.9 ml; area of tumor adhesion: 2434.4 +/- 766 mm2; PCI 28.5 +/- 10.0) of peritoneal dissemination according to all evaluation methods after treatment with phospholipids 6% (tumor volume: 5.2 +/- 2.2 ml; area of tumor adhesion: 1106.8 +/- 689 mm2; PCI 19.0 +/- 5.0) and phospholipids 9% (tumor volume: 4.0 +/- 3.5 ml; area of tumor adhesion: 362.7 +/- 339 mm2; PCI 13.8 +/- 5.1). In experiment B we found a significant reduction of tumor volume in all different groups of rising tumor cell concentration compared to the control. As detected by the area of attachment we found a significant reduction in the subgroups 1*104, 25*104 and 50*104. The reduction in the other subgroups shows no significance. The PCI could be reduced significantly in all subgroups apart from 5*104.
conclusionIn this animal study intraperitoneal application of phospholipids resulted in reduction of the extent of peritoneal carcinomatosis after intraperitoneal administration of free tumor cells. This effect was exceptionally noticed when the amount of intraperitoneal tumor cells was limited. Consequently, intraperitoneal administration of phospholipids might be effective in reducing peritoneal carcinomatosis after surgery of gastrointestinal tumors in humans.
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