ReviewThe Journal of physiology2007
Why some of us get fat and what we can do about it.
Review in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Enhanced anxiety-like behavior emerges with weight gain in male and female obesity-susceptible rats.Behavioural brain research · 2019Article
- Centrally administered urocortin 2 decreases gorging on high-fat diet in both diet-induced obesity-prone and -resistant rats.International journal of obesity (2005) · 2013Article
- Replication and extension of association between common genetic variants in SIM1 and human adiposity.Obesity (Silver Spring, Md.) · 2011Article
- Biology's response to dieting: the impetus for weight regain.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Review
- Developmental gene x environment interactions affecting systems regulating energy homeostasis and obesity.Frontiers in neuroendocrinology · 2010Review
- Decreased food intake following overfeeding involves leptin-dependent and leptin-independent mechanisms.Physiology & behavior · 2010Article
- Effects of maternal genotype and diet on offspring glucose and fatty acid-sensing ventromedial hypothalamic nucleus neurons.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Diet-induced obese mice are leptin insufficient after weight reduction.Obesity (Silver Spring, Md.) · 2009Article
- The effect of neurohormonal factors, epigenetic factors, and gut microbiota on risk of obesity.Preventing chronic disease · 2009Article
- Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice.Genes & nutrition · 2009Article
- Weight-loss maintenance in successful weight losers: surgical vs non-surgical methods.International journal of obesity (2005) · 2009Article
- Leptin resistance and the response to positive energy balance.Physiology & behavior · 2008Review
- Obesity in primary care: evidence for advising weight constancy rather than weight loss in unsuccessful dieters.The British journal of general practice : the journal of the Royal College of General Practitioners · 2008Article
- Obesity and the central nervous system.The Journal of physiology · 2007Article
- The Obesities: An Overview of Convergent and Divergent Paradigms.American journal of lifestyle medicineArticle
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a widespread obesity epidemic in the developed world which is having an adverse impact on the health of affected individuals. Many of the afflicted have a genetic predisposition to become obese. These individuals become obese when they over consume highly palatable, calorically dense foods which are readily available at low cost. Once obesity occurs, fewer than 10% of affected individuals can sustain significant weight loss permanently. The hypothesis of this review is that some obesity-prone individuals have an inborn reduction in their ability to sense and respond to inhibitory signals from adipose stores and other organs which should limit their intake of energy when it exceeds their metabolic needs. Furthermore, the physiological processes which drive all of us to seek and ingest food and limit energy expenditure during periods of negative energy balance provide an irresistible drive to regain lost adipose stores in weight-reduced obese individuals. For this reason, prevention of obesity and the identification factors which promote the development of neural pathways which enhance the negative feedback signals from the periphery should be a major focus of ongoing research in this field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.