Trial reportPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2007
Efficacy of prednisolone in children hospitalized for recurrent wheezing.
Trial report in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Adverse Events Following Short-Course Systemic Corticosteroids Among Children and Adolescents: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Safety of corticosteroids in young children with acute respiratory conditions: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Efficacy of oral corticosteroids in the treatment of acute wheezing episodes in asthmatic preschoolers: Systematic review with meta-analysis.Pediatric pulmonology · 2016Pooled it
- Inhaled corticosteroids for subacute cough in children.The Cochrane database of systematic reviews · 2013Pooled it
- Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2010Trial
- Atopic characteristics of wheezing children and responses to prednisolone.Pediatric pulmonology · 2007Trial
- State of art of oral corticosteroids in children with acute asthma and wheezing.Italian journal of pediatrics · 2026Review
- Safety of corticosteroids in the treatment of acute respiratory disease in children: a systematic review and meta-analysis.Translational pediatrics · 2022Article
- Big Data, Data Science, and Causal Inference: A Primer for Clinicians.Frontiers in medicine · 2021Review
- Respiratory pathogens and clinical outcomes in children with an asthma exacerbation: A systematic review.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2019Review
- An update on the efficacy of oral corticosteroids in the treatment of wheezing episodes in preschool children.Therapeutic advances in respiratory disease · 2014Review
- Observational
- New molecular virus detection methods and their clinical value in lower respiratory tract infections in children.Paediatric respiratory reviews · 2013Review
- Bronchial hyperresponsiveness in an adult population in Helsinki: decreased FEV1 , the main determinant.The clinical respiratory journal · 2013Article
- Steroid responsiveness and wheezing phenotypes.Paediatric respiratory reviews · 2011Review
- Impulse oscillometry in the evaluation of diseases of the airways in children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2011Review
- Nasopharyngeal bacterial colonization during the first wheezing episode is associated with longer duration of hospitalization and higher risk of relapse in young children.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011Article
- Low serum 25-hydroxyvitamin D levels are associated with increased risk of viral coinfections in wheezing children.The Journal of allergy and clinical immunology · 2010Article
- Correlation of viral load of respiratory pathogens and co-infections with disease severity in children hospitalized for lower respiratory tract infection.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2010Article
- Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology.Clinical microbiology reviews · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Data on the efficacy of corticosteroids on respiratory picornavirus-induced wheezing are limited. To determine whether prednisolone is effective in rhinovirus- or enterovirus-induced recurrent wheezing, we conducted a controlled trial comparing oral prednisolone (2 mg/kg/day in three divided doses for 3 days) with placebo in hospitalized wheezing children and studied post hoc virus-specific efficacy in early wheezing (<3 episodes, reported elsewhere) and in recurrent wheezing (>or=3 episodes). Virus-negative children where excluded. Our primary endpoint was the time until children were ready for discharge. Secondary endpoints included oxygen saturation and exhaled nitric oxide during hospitalization, duration of symptoms, blood eosinophil count, and impulse oscillometry 2 wk after discharge, and occurrence of relapses during the following 2 months. Virus-specific effects were analyzed with interaction analysis in a multivariate regression model. During the study period, 661 patients were hospitalized, 293 randomized, and 59 were accepted in this analysis (mean age 2.6 yr, s.d. 1.3). Prednisolone did not significantly decrease the time until ready for discharge in all patients (prednisolone vs. placebo, medians, 18 vs. 24 h, p = 0.11). However, prednisolone decreased the time until ready for discharge in children with picornavirus infection (respectively, 12 vs. 24 h, p = 0.0022) and more specifically, in children with enterovirus infection (6 vs. 35 h, p = 0.0007). In the secondary endpoints, prednisolone decreased the duration of cough and dyspnea in rhinovirus-affected children (p = 0.033 for both). Prospectively designed clinical trial is needed to test the hypothesis that prednisolone reduces symptoms in picornavirus-affected wheezing children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.