ReviewCurrent topics in medicinal chemistry2007
Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor.
Review in Current topics in medicinal chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Generation of an MC3R knock-out pig by CRSPR/Cas9 combined with somatic cell nuclear transfer (SCNT) technology.Lipids in health and disease · 2019Article
- Novel approaches to the design of bioavailable melanotropins.Expert opinion on drug discovery · 2017Review
- Article
- Protein-Protein Interactions as New Targets for Ion Channel Drug Discovery.Austin journal of pharmacology and therapeutics · 2013Article
- Development and in vivo quantitative magnetic resonance imaging of polymer micelles targeted to the melanocortin 1 receptor.Journal of medicinal chemistry · 2013Article
- In vivo and in silico pharmacokinetics and biodistribution of a melanocortin receptor 1 targeted agent in preclinical models of melanoma.Molecular pharmaceutics · 2013Article
- Melanocortin-3-receptor promoter polymorphism associated with tuberculosis susceptibility does not influence protein expression.BMC research notes · 2013Article
- Design of peptide and peptidomimetic ligands with novel pharmacological activity profiles.Annual review of pharmacology and toxicology · 2013Review
- Cardiovascular effects of melanocortins.European journal of pharmacology · 2011Review
- Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors.Bioorganic & medicinal chemistry letters · 2011Article
- Melanocortin-4 receptor gene polymorphism and the level of physical activity in men (HALS Study).Endocrine · 2011Article
- Article
- Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies.Journal of the American Chemical Society · 2010Article
- Novel binding motif of ACTH analogues at the melanocortin receptors.Biochemistry · 2009Article
- Melanotropins as drugs for the treatment of obesity and other feeding disorders: potential and problems.Current topics in medicinal chemistry · 2009Review
- Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor.Journal of medicinal chemistry · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The processed products of the proopiomelanocortin gene (ACTH, alpha-MSH, beta-MSH, gamma-MSH, etc.) interact with five melanocortin receptors, the MC1R, MC2R, MC3R, MC4R, and MC5R to modulate and control many important biological functions crucial for good health both peripherally (as hormones) and centrally (as neurotransmitters). Pivotal biological functions include pigmentation, adrenal function, response to stress, fear/flight, energy homeostasis, feeding behavior, sexual function and motivation, pain, immune response, and many others, and are believed to be involved in many disease states including pigmentary disorders, adrenal disorders, obesity, anorexia, prolonged and neuropathic pain, inflammatory response, etc. The melanocortin-3 receptor (MC3R) is found primarily in the brain and spinal cord and also in the periphery, and its biological functions are still not well understood. Here we review some of the biological functions attributed to the MC3R, and then examine in more detail efforts to design and synthesize ligands that are potent and selective for the MC3R, which might help resolve the many questions still remaining about its function. Though some progress has been made, there is still much to be done in this critical area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.