Evidence map›Paper›PMID 17583796›Full record

Trial reportDiabetologia2007

A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease.

S Lindeberg, T Jönsson, Y Granfeldt, E Borgstrand, J Soffman, K Sjöström, B Ahrén

3 registry-linked trialsOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Diabetologia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 76 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 9 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00419497 phase2 / phase3completednot on this map

Paleolithic Diet in the Treatment of Glucose Intolerance

TypeinterventionalSponsorLund University HospitalRan2003 to 2007Enrolled29ConditionsHyperglycemia, Coronary Heart DiseaseArmsPaleolithic diet vs Mediterranean diet
NCT01208558 phase2 / phase3completednot on this mapstarted 2010, after this paper: background citation

Whole Grain Versus no Grain With or Without Physiotherapy-promoted Exercise for Waist Loss

TypeinterventionalSponsorLund UniversityRan2010 to 2014Enrolled105ConditionsAbdominal Obesity, Cardiovascular Diseases, Diabetes Type 2, HypertensionArmsDiet A, Diet B, Physiotherapy
NCT01891955 nacompletednot on this mapstarted 2013, after this paper: background citation

Alimentation and Diabetes in Lanzarote - ADILAN: a Randomized Cross-over Pilot Trial Comparing a Healthy Diet With Grains and Dairy to a Healthy Diet Without Grains and Dairy in Patients With Type 2 Diabetes

TypeinterventionalSponsorLund UniversityRan2013 to 2014Enrolled14ConditionsType 2 DiabetesArmsHealthy diet A, Healthy diet B
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 9 syntheses or guidelines pooled it, 276 citations in OpenAlex.

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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

S LindebergDepartment of Medicine, Hs 32, University of Lund, SE-221 85, Lund, Sweden. staffan.lindeberg@med.lu.se.
T JönssonDepartment of Medicine, Hs 32, University of Lund, SE-221 85, Lund, Sweden.
Y GranfeldtDepartment of Applied Nutrition and Food Chemistry, University of Lund, Lund, Sweden.
E BorgstrandDepartment of Medicine, Hs 32, University of Lund, SE-221 85, Lund, Sweden.
J SoffmanDepartment of Medicine, Hs 32, University of Lund, SE-221 85, Lund, Sweden.
K SjöströmDepartment of Medicine, Hs 32, University of Lund, SE-221 85, Lund, Sweden.
B AhrénDepartment of Medicine, Hs 32, University of Lund, SE-221 85, Lund, Sweden.
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisMost studies of diet in glucose intolerance and type 2 diabetes have focused on intakes of fat, carbohydrate, fibre, fruits and vegetables. Instead, we aimed to compare diets that were available during human evolution with more recently introduced ones.

methodsTwenty-nine patients with ischaemic heart disease plus either glucose intolerance or type 2 diabetes were randomised to receive (1) a Palaeolithic ('Old Stone Age') diet (n = 14), based on lean meat, fish, fruits, vegetables, root vegetables, eggs and nuts; or (2) a Consensus (Mediterranean-like) diet (n = 15), based on whole grains, low-fat dairy products, vegetables, fruits, fish, oils and margarines. Primary outcome variables were changes in weight, waist circumference and plasma glucose AUC (AUC Glucose(0-120)) and plasma insulin AUC (AUC Insulin(0-120)) in OGTTs.

resultsOver 12 weeks, there was a 26% decrease of AUC Glucose(0-120) (p = 0.0001) in the Palaeolithic group and a 7% decrease (p = 0.08) in the Consensus group. The larger (p = 0.001) improvement in the Palaeolithic group was independent (p = 0.0008) of change in waist circumference (-5.6 cm in the Palaeolithic group, -2.9 cm in the Consensus group; p = 0.03). In the study population as a whole, there was no relationship between change in AUC Glucose(0-120) and changes in weight (r = -0.06, p = 0.9) or waist circumference (r = 0.01, p = 1.0). There was a tendency for a larger decrease of AUC Insulin(0-120) in the Palaeolithic group, but because of the strong association between change in AUC Insulin(0-120) and change in waist circumference (r = 0.64, p = 0.0003), this did not remain after multivariate analysis. CONCLUSIONS/

interpretationA Palaeolithic diet may improve glucose tolerance independently of decreased waist circumference.

Indexed as

DietDiet, MediterraneanPaleontologyAgedArea Under CurveBlood GlucoseBody Mass IndexDiabetes Mellitus, Type 2Diabetic AngiopathiesGlucose Tolerance TestGlycated HemoglobinHumansInsulinMiddle AgedMyocardial IschemiaBlood GlucoseGlycated HemoglobinInsulin

Identifiers

PMID17583796
OpenAlexW2132106453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.