ArticleJournal of the American Society for Mass Spectrometry2007
Improved sequencing of oxidized cysteine and methionine containing peptides using electron transfer dissociation.
Article in Journal of the American Society for Mass Spectrometry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Top-Down ETD-MS Provides Unreliable Quantitation of Methionine Oxidation.Journal of biomolecular techniques : JBT · 2019Article
- w-Type ions formed by electron transfer dissociation of Cys-containing peptides investigated by infrared ion spectroscopy.Journal of mass spectrometry : JMS · 2018Article
- Noncatalytic Antioxidant Role for Helicobacter pylori Urease.Journal of bacteriology · 2018Article
- Covalent labeling-mass spectrometry with non-specific reagents for studying protein structure and interactions.Methods (San Diego, Calif.) · 2018Review
- Supercharging by m-NBA Improves ETD-Based Quantification of Hydroxyl Radical Protein Footprinting.Journal of the American Society for Mass Spectrometry · 2015Article
- Mass spectrometry-based methods for identifying oxidized proteins in disease: advances and challenges.Biomolecules · 2015Review
- Quantitative protein topography analysis and high-resolution structure prediction using hydroxyl radical labeling and tandem-ion mass spectrometry (MS).Molecular & cellular proteomics : MCP · 2015Article
- Characteristic tandem mass spectral features under various collision chemistries for site-specific identification of protein S-glutathionylation.Journal of the American Society for Mass Spectrometry · 2015Article
- A synchrotron-based hydroxyl radical footprinting analysis of amyloid fibrils and prefibrillar intermediates with residue-specific resolution.Biochemistry · 2014Article
- Oxidation-induced conformational changes in calcineurin determined by covalent labeling and tandem mass spectrometry.Biochemistry · 2014Article
- Improved identification and relative quantification of sites of peptide and protein oxidation for hydroxyl radical footprinting.Journal of the American Society for Mass Spectrometry · 2013Article
- Negative ion fragmentation of cysteic acid containing peptides: cysteic acid as a fixed negative charge.Journal of the American Society for Mass Spectrometry · 2011Article
- Elucidating the higher-order structure of biopolymers by structural probing and mass spectrometry: MS3D.Journal of mass spectrometry : JMS · 2010Article
- On the charge partitioning between c and z fragments formed after electron-capture induced dissociation of charge-tagged Lys-Lys and Ala-Lys dipeptide dications.Journal of the American Society for Mass Spectrometry · 2009Article
- Correct identification of oxidized histidine residues using electron-transfer dissociation.Journal of mass spectrometry : JMS · 2009Article
- Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells.The Journal of biological chemistry · 2009Article
- Comparison of infrared multiphoton dissociation and collision-induced dissociation of supercharged peptides in ion traps.Journal of the American Society for Mass Spectrometry · 2009Article
- Article
- Electron-capture-induced dissociation of protoporphyrin IX ions.Journal of the American Society for Mass Spectrometry · 2008Article
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Authors and funding
8 authors.
Funding
Abstract
Oxidative modifications to the side chains of sulfur-containing amino acids often limit the number of product ions formed during collision-induced dissociation (CID) and thus make it difficult to obtain sequence information for oxidized peptides. In this work, we demonstrate that electron-transfer dissociation (ETD) can be used to improve the sequence information obtained from peptides with oxidized cysteine and methionine residues. In contrast to CID, ETD is found to be much less sensitive to the side-chain chemistry, enabling extensive sequence information to be obtained in cases where CID fails to provide this information. These results indicate that ETD is a valuable technique for studying oxidatively modified peptides and proteins. In addition, we report a unique and very abundant product ion that is formed in the CID spectra of peptides having N-terminal cysteine sulfinic acid residues. The mechanism for this unique dissociation pathway involves a six-membered cyclic intermediate and leads to the facile loss of NH(3) and SO(2), which corresponds to a mass loss of 81 Da. While the facile nature of this dissociation pathway limits the sequence information present in CID spectra of peptides with N-terminal cysteine sulfinic acid residues, extensive sequence information for these peptides can be obtained with ETD.
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Registered trials
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