ArticleGeneral and comparative endocrinology2008
Local expression of CYP19A1 and CYP19A2 in developing and adult killifish (Fundulus heteroclitus).
Article in General and comparative endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Steroidogenic acute regulatory protein in fish.The Journal of endocrinology · 2025Review
- Article
- Insights into Early Ontogenesis ofAnimals : an open access journal from MDPI · 2023Article
- Detrimental Effects of Bisphenol Compounds on Physiology and Reproduction in Fish: A Literature Review.Environmental toxicology and pharmacology · 2021Review
- Molecular Characterization and Expression of Cytochrome P450 Aromatase in Atlantic Croaker Brain: Regulation by Antioxidant Status and Nitric Oxide Synthase During Hypoxia Stress.Frontiers in physiology · 2021Article
- Direct and Indirect Effects of Sex Steroids on Gonadotrope Cell Plasticity in the Teleost Fish Pituitary.Frontiers in endocrinology · 2020Review
- Identification of Differentially Expressed Genes in Porcine Ovaries at Proestrus and Estrus Stages Using RNA-Seq Technique.BioMed research international · 2018Article
- Neuroendocrine disruption of organizational and activational hormone programming in poikilothermic vertebrates.Journal of toxicology and environmental health. Part B, Critical reviews · 2017Review
- Benzo[a]pyrene effects on reproductive endpoints in Fundulus heteroclitus.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Dimorphic expression of various transcription factor and steroidogenic enzyme genes during gonadal ontogeny in the air-breathing catfish, Clarias gariepinus.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2011Article
- Benzo[a]pyrene effects on glycine N-methyltransferase mRNA expression and enzyme activity in Fundulus heteroclitus embryos.Aquatic toxicology (Amsterdam, Netherlands) · 2010Article
- Benzo(a)pyrene decreases brain and ovarian aromatase mRNA expression in Fundulus heteroclitus.Aquatic toxicology (Amsterdam, Netherlands) · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
P450 aromatase (CYP19) is the terminal enzyme in the steroidogenic pathway and catalyzes the conversion of androgens to estrogens. Fundulus heteroclitus like other teleosts, express two CYP19 genes, CYP19A1 and CYP19A2. The expression of CYP19s in Fundulus was measured by in situ hybridization throughout development. In 90 dpf (day post-fertilization) fish and adult fish, CYP19A1 was expressed in the ooplasm of early stage I oocytes (primary growth stage). Expression of CYP19A1 was localized in the follicle cell layer of late stage I (previtellogenic stage) and stage II (vitellogenic stage) follicles, but by stage III (early maturational follicles) CYP19A1 expression was localized in the vitelline envelope. Overall, CYP19A1 oocyte membrane expression gradually declined from highest expression at late stage I to nondetectable levels by stage IV. Highest expression of CYP19A2 was detected in the brain including the hypothalamus from 4, 6, 8, 10, 14 dpf embryos, 90 dpf fry fish and adult fish brain. In females compared to males, there was higher CYP19A2 expression in olfactory bulb. In addition to the brain, there was strong CYP19A2 signal in adrenal/kidney cells in 6-14 dpf embryos. This work establishes the localization and constitutive expression of CYP19s in Fundulus which can then be compared with potential disruption of CYP19A1 and CYP19A2 expression and physiological consequences caused by environmental contaminants.
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