ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Convergent motor patterns from divergent circuits.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 64 citations in OpenAlex.
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- Decoding Neuropeptide Complexity: Advancing Neurobiological Insights from Invertebrates to Vertebrates through Evolutionary Perspectives.ACS chemical neuroscience · 2025Review
- Neuropeptide Modulation Enables Biphasic Internetwork Coordination via a Dual-Network Neuron.eNeuro · 2024Article
- Switching neuron contributions to second network activity.Journal of neurophysiology · 2024Article
- Modulation by Neuropeptides with Overlapping Targets Results in Functional Overlap in Oscillatory Circuit Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Convergent effects of neuropeptides on the feeding central pattern generator ofJournal of neurophysiology · 2022Article
- Perturbation-specific responses by two neural circuits generating similar activity patterns.Current biology : CB · 2021Article
- Article
- Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates.International journal of molecular sciences · 2021Review
- Chronic vs acute manipulations reveal degeneracy in a thermosensory neuron network.microPublication biology · 2021Article
- Different microcircuit responses to comparable input from one versus both copies of an identified projection neuron.The Journal of experimental biology · 2020Article
- Feeding state functionally reconfigures a sensory circuit to drive thermosensory behavioral plasticity.eLife · 2020Article
- Similarities and differences in circuit responses to applied GlyJournal of neurophysiology · 2019Article
- AMGSEFLamide, a member of a broadly conserved peptide family, modulates multiple neural networks inThe Journal of experimental biology · 2019Article
- Two central pattern generators from the crab,eLife · 2018Article
- General Principles of Neuronal Co-transmission: Insights From Multiple Model Systems.Frontiers in neural circuits · 2018Review
- State-dependent sensorimotor gating in a rhythmic motor system.Journal of neurophysiology · 2017Article
- Complicating connectomes: Electrical coupling creates parallel pathways and degenerate circuit mechanisms.Developmental neurobiology · 2017Review
- Convergent neuromodulation onto a network neuron can have divergent effects at the network level.Journal of computational neuroscience · 2016Article
- Neural and genetic degeneracy underlies Caenorhabditis elegans feeding behavior.Journal of neurophysiology · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neuromodulation changes the cellular and synaptic properties of neurons, thereby enabling individual neuronal circuits to generate multiple activity patterns. However, distinct modulatory inputs could conceivably also cona different motor circuits to generate similar activity patterns. Using the isolated stomatogastric ganglion (STG) of the crab Cancer borealis, we showed previously that pyrokinin (PK) peptides activate the gastric mill (chewing) rhythm without the participation of the projection neuron modulatory commissural neuron 1 (MCN1). MCN1, which does not contain the PK peptide, also activates the gastric mill rhythm and, at these times, is a gastric mill central pattern generator (CPG) neuron. Here, we show that the gastric mill rhythms elicited by PK superfusion and MCN1 stimulation in the isolated STG are comparable, in contrast to the distinct gastric mill rhythms elicited by other input pathways. We also identified several cellular and synaptic mechanisms underlying the PK- and MCN1-elicited gastric mill rhythms that are distinct, including additional differences in their core CPG neurons. For example, the presence of the inhibitory synapse from the pyloric pacemaker neuron anterior burster onto the gastric mill CPG was necessary only for generation of the PK-elicited gastric mill rhythm. Similarly, the dorsal gastric motor neuron regulated only the PK rhythm, apparently because of PK-mediated enhancement of its synaptic actions. Thus, we demonstrate that different modulatory inputs can elicit comparable, as well as distinct activity patterns from the same neuronal ensemble. Moreover, these comparable rhythms can result from distinct CPGs using overlapping, but distinct sets of cellular and synaptic mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.