ArticleMolecular biology of the cell2007
G protein signaling governing cell fate decisions involves opposing Galpha subunits in Cryptococcus neoformans.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Review
- Unisexual reproduction in the global human fungal pathogenProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Unisexual reproduction in the global human fungal pathogenbioRxiv : the preprint server for biology · 2025Article
- The nematode-trapping fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors.Nature microbiology · 2024Article
- Ontogenetic Variation in Macrocyclic and Hemicyclic Poplar Rust Fungi.International journal of molecular sciences · 2022Article
- Role of the Heme Activator Protein Complex in the Sexual Development of Cryptococcus neoformans.mSphere · 2022Article
- Cryptococcus neoformans: Sex, morphogenesis, and virulence.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Review
- Coregulation of dimorphism and symbiosis by cyclic AMP signaling in the lichenized fungusProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Natural diversity in the predatory behavior facilitates the establishment of a robust model strain for nematode-trapping fungi.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Environmental Factors That Contribute to the Maintenance ofMicroorganisms · 2020Review
- Article
- Life Cycle ofAnnual review of microbiology · 2019Review
- Unisexual reproduction promotes competition for mating partners in the global human fungal pathogen Cryptococcus deneoformans.PLoS genetics · 2019Article
- The cAMP/Protein Kinase a Pathway Regulates Virulence and Adaptation to Host Conditions inFrontiers in cellular and infection microbiology · 2019Review
- Cryptococcus neoformans sexual reproduction is controlled by a quorum sensing peptide.Nature microbiology · 2018Article
- PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex.PLoS genetics · 2017Article
- Connecting virulence pathways to cell-cycle progression in the fungal pathogen Cryptococcus neoformans.Current genetics · 2017Review
- Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation.PLoS genetics · 2017Article
- Pheromone independent unisexual development in Cryptococcus neoformans.PLoS genetics · 2017Article
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3 authors.
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Abstract
Communication between cells and their environments is often mediated by G protein-coupled receptors and cognate G proteins. In fungi, one such signaling cascade is the mating pathway triggered by pheromone/pheromone receptor recognition. Unlike Saccharomyces cerevisiae, which expresses two Galpha subunits, most filamentous ascomycetes and basidiomycetes have three Galpha subunits. Previous studies have defined the Galpha subunit acting upstream of the cAMP-protein kinase A pathway, but it has been unclear which Galpha subunit is coupled to the pheromone receptor and response pathway. Here we report that in the pathogenic basidiomycetous yeast Cryptococcus neoformans, two Galpha subunits (Gpa2, Gpa3) sense pheromone and govern mating. gpa2 gpa3 double mutants, but neither gpa2 nor gpa3 single mutants, are sterile in bilateral crosses. By contrast, deletion of GPA3 (but not GPA2) constitutively activates pheromone response and filamentation. Expression of GPA2 and GPA3 is differentially regulated: GPA3 expression is induced by nutrient-limitation, whereas GPA2 is induced during mating. Based on the phenotype of dominant active alleles, Gpa2 and Gpa3 signal in opposition: Gpa2 promotes mating, whereas Gpa3 inhibits. The incorporation of an additional Galpha into the regulatory circuit enabled increased signaling complexity and facilitated cell fate decisions involving choice between yeast growth and filamentous asexual/sexual development.
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