ArticleMolecular biology of the cell2007
The concentration of Nuf, a Rab11 effector, at the microtubule-organizing center is cell cycle regulated, dynein-dependent, and coincides with furrow formation.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 59 citations in OpenAlex.
- Distinct Rab11-associated membrane trafficking pathways bidirectionally control neuronal extracellular vesicle cargo traffic.bioRxiv : the preprint server for biology · 2026Article
- Cytoplasmic localization of the mRNA encoding actin regulator, Serendipity-bioRxiv : the preprint server for biology · 2025Article
- Reshaping the Syncytial Drosophila Embryo with Cortical Actin Networks: Four Main Steps of Early Development.Results and problems in cell differentiation · 2024Review
- Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins.Developmental cell · 2021Article
- Conserved role for Ataxin-2 in mediating endoplasmic reticulum dynamics.Traffic (Copenhagen, Denmark) · 2019Article
- Article
- Coordination of Embryogenesis by the Centrosome in Drosophila melanogaster.Results and problems in cell differentiation · 2019Review
- Review
- Nuf and Rip11 requirement for polarity determinant recycling during Drosophila development.Small GTPases · 2018Article
- The endoplasmic reticulum is partitioned asymmetrically during mitosis before cell fate selection in proneuronal cells in the earlyMolecular biology of the cell · 2017Article
- Polo kinase mediates the phosphorylation and cellular localization of Nuf/FIP3, a Rab11 effector.Molecular biology of the cell · 2017Article
- Shot and Patronin polarise microtubules to direct membrane traffic and biogenesis of microvilli in epithelia.Journal of cell science · 2016Article
- Article
- A transport and retention mechanism for the sustained distal localization of Spn-F-IKKε during Drosophila bristle elongation.Development (Cambridge, England) · 2015Article
- Endocytic transport and cytokinesis: from regulation of the cytoskeleton to midbody inheritance.Trends in cell biology · 2013Review
- The BAR domain of amphiphysin is required for cleavage furrow tip-tubule formation during cellularization in Drosophila embryos.Molecular biology of the cell · 2013Article
- BDNF regulates Rab11-mediated recycling endosome dynamics to induce dendritic branching.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Rab11 regulates cell-cell communication during collective cell movements.Nature cell biology · 2013Article
- RhoGEF and positioning of rappaport-like furrows in the early Drosophila embryo.Current biology : CB · 2012Article
- Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking.The Journal of cell biology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Animal cytokinesis relies on membrane addition as well as acto-myosin-based constriction. Recycling endosome (RE)-derived vesicles are a key source of this membrane. Rab11, a small GTPase associated with the RE and involved in vesicle targeting, is required for elongation of the cytokinetic furrow. In the early Drosophila embryo, Nuclear-fallout (Nuf), a Rab11 effector, promotes vesicle-mediated membrane delivery and actin organization at the invaginating furrow. Although Rab11 maintains a relatively constant localization at the microtubule-organizing center (MTOC), Nuf is present at the MTOC only during the phases of the cell cycle in which furrow invagination occurs. We demonstrate that Nuf protein levels remain relatively constant throughout the cell cycle, suggesting that Nuf is undergoing cycles of concentration and dispersion from the MTOC. Microtubules, but not microfilaments, are required for proper MTOC localization of Nuf and Rab11. The MTOC localization of Nuf also relies on Dynein. Immunoprecipitation experiments demonstrate that Nuf and Dynein physically interact. In accord with these findings, and in contrast to previous reports, we demonstrate that microtubules are required for proper metaphase furrow formation. We propose that the cell cycle-regulated, Dynein-dependent recruitment of Nuf to the MTOC influences the timing of RE-based vesicle delivery to the invaginating furrows.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.