ArticleGenes and immunity2007
Strong associations of psoriasis with antigen processing LMP and transport genes TAP differ by gender and phenotype.
Article in Genes and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Therapeutic mechanism of Pithecellobium clypearia Benth. on imiquimod-induced psoriasis revealed by tissue transcriptomics in mice.PloS one · 2025Article
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- Variations inInternational journal of general medicine · 2021Article
- Reduced Proteasome Activity and Enhanced Autophagy in Blood Cells of Psoriatic Patients.International journal of molecular sciences · 2020Article
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- A genetic risk score for thyroid peroxidase antibodies associates with clinical thyroid disease in community-based populations.The Journal of clinical endocrinology and metabolism · 2015Article
- High-density genotyping of immune loci in Kawasaki disease and IVIG treatment response in European-American case-parent trio study.Genes and immunity · 2014Article
- Self-antigen presentation by dendritic cells in autoimmunity.Frontiers in immunology · 2014Review
- HLA Immune Function Genes in Autism.Autism research and treatment · 2012Article
- Immunoproteasomes: structure, function, and antigen presentation.Progress in molecular biology and translational science · 2012Review
- Molecular genetics of Psoriasis (Principles, technology, gene location, genetic polymorphism and gene expression).International journal of health sciences · 2010Article
- Article
- Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice.PloS one · 2009Article
- Molecular mechanisms of uterine leiomyosarcomas: involvement of defect in LMP2 expression.Gene regulation and systems biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psoriasis, a skin disease with autoimmune features, can be triggered and exacerbated by genetic and environmental factors. Chemicals can break tolerance to self-antigens by interfering with antigen processing and presentation; therefore, proteins involved in antigen processing may affect susceptibility. We test here whether variants of immunoproteasome subunits LMP2 and LMP7, or antigen peptide transport proteins TAP1 (transporters associated with antigen presentation) and TAP2 are associated with psoriasis. We analyzed 7 single-nucleotide polymorphisms in 321 Caucasian (German) psoriasis patients and 235 unrelated controls by time-of-flight mass spectrometry, using the Sequenom platform. We found strong associations of psoriasis with variant alleles of LMP and TAP (OR(TAP_687): 3.3, 95% CI: 1.9-5.7). Genotype effects were generally stronger for males and LMP effects were mainly seen for psoriasis arthropathica. Our results will help define behavioral or drug treatment suggestions to patients and contribute to a better understanding of the role of low molecular weight chemicals in genetic susceptibility to autoimmune diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.