Evidence map›Paper›PMID 17580897›Full record

ReviewThe Journal of organic chemistry2007

The diverse roles of flavin coenzymes--nature's most versatile thespians.

Steven O Mansoorabadi, Christopher J Thibodeaux, Hung-wen Liu

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of organic chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 195 citations in OpenAlex.

  1. Article
  2. Article
  3. Photoenzymatic CspProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Vitamin BACS central science · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Article
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  11. Article
  12. Review
  13. Article
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  17. Review
  18. Review
  19. Article
  20. Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Steven O MansoorabadiDivision of Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, Texas 78712, USA.
Christopher J Thibodeaux
Hung-wen Liu
The University of Texas at Austin · US

Funding

Three-Membered Ring Metabolites, Inhibition &FormationR01GM040541 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI LIU, HUNG-WEN · 1989 to 2023
$7.4M
Mechanistic Studies of Deoxy Sugar BiosynthesisR01GM035906 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI LIU, HUNG-WEN · 1986 to 2023
$6.1M
MECHANISMS OF BIOSYNTHETIC FORMATION OF DEOXY SUGARSR37GM035906 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI LIU, HUNG-WEN · 1999 to 2008
$3.4M
MECHANISMS OF BIOSYNTHESIS OF BRANCHED-CHAIN SUGARSR01GM054346 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI LIU, HUNG-WEN · 1996 to 2007
$2.3M
NIGMS NIH HHS R01 GM035906NIGMS NIH HHS R01 GM040541NIGMS NIH HHS R01 GM054346NIGMS NIH HHS R37 GM035906
6 · The paper itself

Abstract

Flavin coenzymes play a variety of roles in biological systems. This Perspective highlights the chemical versatility of flavins by reviewing research on five flavoenzymes that have been studied in our laboratory. Each of the enzymes discussed in this review [the acyl-CoA dehydrogenases (ACDs), CDP-6-deoxy-l-threo-d-glycero-4-hexulose-3-dehydrase reductase (E3), CDP-4-aceto-3,6-dideoxygalactose synthase (YerE), UDP-galactopyranose mutase (UGM), and type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IDI-2)] utilizes flavin in a distinct role. In particular, the catalytic mechanisms of two of these enzymes, UGM and IDI-2, may involve novel flavin chemistry.

Indexed as

CatalysisCoenzymesFlavinsModels, MolecularOxidation-ReductionCoenzymesFlavins

Identifiers

PMID17580897
PMCPMC2519020
OpenAlexW2181038014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.