ArticleSleep2007
The effect of acute intermittent hypercapnic hypoxia treatment on IL-6, TNF-alpha, and CRP levels in piglets.
Article in Sleep, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Dietary Supplementation with Algal-Derived Oligosaccharides: Impacts on the Growth Potential, Systemic Immunity, and Cecal Microbiota of Weaned Piglets.Animals : an open access journal from MDPI · 2026Article
- A case-control study to investigate the prevalence of obstructive sleep apnea and the utility of the Sleep-Related Breathing Disorder scale of the Pediatric Sleep Questionnaire in children and young people with epilepsy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Obstructive Sleep Apnea Disrupts Glycemic Control in Obese Individuals.Medicina (Kaunas, Lithuania) · 2022Article
- Evaluation the Possible Role of Interleukin-6 and Tumor Necrosis Factor- Alpha in Pathogenesis of Obstructive Sleep Apnea in Obese Patients: A Case-Control Study:.Galen medical journal · 2022Article
- Comparative study of yeast selenium vs. sodium selenite on growth performance, nutrient digestibility, anti-inflammatory and anti-oxidative activity in weaned piglets challenged byInnate immunity · 2020Article
- Dietary Addition of Antioxidant Complex Packs and Functional Amino Acids Can Improve the Digestion, Absorption, and Immunity of Huanjiang Minipigs.BioMed research international · 2020Article
- OSA and Cardiovascular Risk in Pediatrics.Chest · 2019Review
- Biochemical markers of cardiac dysfunction in children with obstructive sleep apnoea (OSA).Sleep & breathing = Schlaf & Atmung · 2019Article
- The Role of Acute Intermittent Hypoxia in Neutrophil-Generated Superoxide, Sympathovagal Balance, and Vascular Function in Healthy Subjects.Frontiers in physiology · 2017Article
- Article
- Evaluation of the association of sleep apnea-related systemic inflammation with CRP, ESR, and neutrophil-to-lymphocyte ratio.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- The platelet-to-lymphocyte ratio reflects the severity of obstructive sleep apnea syndrome and concurrent hypertension.Clinical hypertension · 2015Article
- Intermittent hypoxia in childhood: the harmful consequences versus potential benefits of therapeutic uses.Frontiers in pediatrics · 2015Review
- Therapeutic potential of intermittent hypoxia: a matter of dose.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Review
- Investigation and management of childhood sleep apnoea.Hippokratia · 2013Review
- Targeting tumour necrosis factor-α in hypoxia and synaptic signalling.Irish journal of medical science · 2013Review
- Atrial arrhythmias in obstructive sleep apnea: underlying mechanisms and implications in the clinical setting.Pulmonary medicine · 2013Article
- Effects of 10 days of modest intermittent hypoxia on circulating measures of inflammation in healthy humans.Sleep & breathing = Schlaf & Atmung · 2012Article
- Pro-atherogenic cytokine profile of patients with suspected obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2009Article
- Sleep apnea: a proinflammatory disorder that coaggregates with obesity.The Journal of allergy and clinical immunology · 2008Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
STUDY
objectivesObstructive sleep apnea (OSA) is characterized by repeated episodes of upper-airway obstruction during sleep leading to significant hypercapnic hypoxic conditions. These conditions are associated with increased levels of proinflammatory cytokines (including interleukin [IL]-6, tumor necrosis factor [TNF]-alpha, and C-reactive protein [CRP]) and subsequent increased cardiovascular risk. It is unclear whether hypercapnic hypoxia itself causes inflammatory perturbations.
designWe evaluated circulating IL-6, TNF- a and CRP in a piglet model of infant OSA, following exposure to acute intermittent hypercapnic hypoxia (IHH). Study groups comprised of treatment (n = 8) and control (n = 8) groups. Treatment was two 90-minute sessions of IHH with arterial blood sampled before and after each IHH session. MEASUREMENTS AND
resultsIL-6, TNF-alpha and CRP levels were measured before and after IHH treatment sessions. Results showed an increase in IL-6 following the first session of IHH that was neither sustained, nor repeated, during a subsequent exposure. Using mixed-modelling, TNF-alpha changed between time points and groups. There were no changes in CRP over the duration of the study.
conclusionThese results suggest that acute hypoxia causes a transient increase in IL-6 levels and has implications for the pathogenesis of increased cardiovascular disease in OSA, especially in childhood.
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