ArticleEuropean biophysics journal : EBJ2007
A new concept of olfactory biosensor based on interdigitated microelectrodes and immobilized yeasts expressing the human receptor OR17-40.
Article in European biophysics journal : EBJ, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Advances in cell-based biosensors: Transforming food flavor evaluation with novel approaches.Food chemistry: X · 2025Review
- Field-Effect Sensors Using Biomaterials for Chemical Sensing.Sensors (Basel, Switzerland) · 2021Review
- Immobilization of Olfactory Receptors Carried by Nanosomes onto a Gold Sensor Surface.Methods in molecular biology (Clifton, N.J.) · 2021Article
- The Emergence of Insect Odorant Receptor-Based Biosensors.Biosensors · 2020Review
- Membrane protein-based biosensors.Journal of the Royal Society, Interface · 2018Review
- Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm.The Journal of biological chemistry · 2011Article
- Stimulation of human olfactory receptor 17-40 with odorants probed by surface plasmon resonance.European biophysics journal : EBJ · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work shows the feasibility of an olfactory biosensor based on the immobilization of Saccharomyces cerevisiae yeast cells genetically modified to express the human olfactory receptor OR17-40 onto interdigitated microconductometric electrodes. This olfactory biosensor has been applied to the detection of its specific odorant (helional) with a high sensitivity (threshold 10(-14) M). In contrast, no significant response was observed using a non-specific odorant (heptanal), which suggests a good selectivity. Thus, this work may represent a first step towards a new kind of bioelectronic noses based on whole yeast cells and allowing a real time monitoring of olfactory receptor activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.