ArticlePsychopharmacology2007
Disruption of prepulse inhibition of the startle reflex by the preferential D(3) agonist ropinirole in healthy males.
Article in Psychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Loss of Thy1 in Cortico-Striatal Pathways Alters Response to Dopamine and Gabapentin.ASN neuro · 2026Article
- Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment?Ageing research reviews · 2020Review
- The dopamine D3 receptor gene and posttraumatic stress disorder.Journal of traumatic stress · 2014Article
- cAMP response element binding protein phosphorylation in nucleus accumbens underlies sustained recovery of sensorimotor gating following repeated D₂-like receptor agonist treatment in rats.Biological psychiatry · 2011Article
- Pramipexole effects on startle gating in rats and normal men.Psychopharmacology · 2009Article
- Habituation and sensitization of acoustic startle: opposite influences of dopamine D1 and D2-family receptors.Neurobiology of learning and memory · 2009Article
- Using prepulse inhibition to detect functional D3 receptor antagonism: effects of WC10 and WC44.Pharmacology, biochemistry, and behavior · 2009Article
- Motivated attention and prepulse inhibition of startle in rats: using conditioned reinforcers as prepulses.Behavioral neuroscience · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleEmerging evidence from agonist-antagonist studies suggests a role for the dopamine D(3) receptor subtype in the regulation of PPI in animals, but such evidence is lacking for human subjects.
objectivesThis study examines the effect of the preferential D(3) agonist ropinirole on PPI in humans.
methodsPPI was tested in 12 healthy men in three sessions associated with ropinirole 0.25 mg, ropinirole 0.5 mg, or placebo according to a balanced, crossover, double-blind design. Two prepulses (75- and 85-dB white noise bursts) and two lead intervals (50 and 80 ms) were employed.
resultsRopinirole 0.5 mg significantly reduced prepulse inhibition (PPI) with both prepulses at the 80-ms lead intervals. There was no effect of treatment on startle amplitude and habituation.
conclusionsThese results suggest a role for the dopamine D(3) receptor in the mediation of human PPI, although a contribution from ropinirole's agonistic activity at the D(2) receptor cannot be entirely excluded. Firm conclusions on the role of the D(3) receptor in the modulation of human PPI can only be drawn with the use of genetic approaches or more selective ligands for this receptor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.