ArticlePloS one2007
Patient and regimen characteristics associated with self-reported nonadherence to antiretroviral therapy.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Housing Status, Medical Care, and Health Outcomes Among People Living With HIV/AIDS: A Systematic Review.American journal of public health · 2016Pooled it
- Predictors and correlates of adherence to combination antiretroviral therapy (ART) for chronic HIV infection: a meta-analysis.BMC medicine · 2014Pooled it
- Identification of evidence-based interventions for promoting HIV medication adherence: findings from a systematic review of U.S.-based studies, 1996-2011.AIDS and behavior · 2014Pooled it
- Systematic review: effect of alcohol intake on adherence to outpatient medication regimens for chronic diseases.Journal of studies on alcohol and drugs · 2012Pooled it
- Alcohol use and antiretroviral adherence: review and meta-analysis.Journal of acquired immune deficiency syndromes (1999) · 2009Pooled it
- A Longitudinal Analysis of Antiretroviral Adherence Among Young Black Men Who Have Sex With Men.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2017Trial
- Antiretroviral Therapy Use and Disparities Among Medicare Beneficiaries with HIV.Journal of general internal medicine · 2024Observational
- Understanding disparities in viral suppression among Black MSM living with HIV in Atlanta Georgia.Journal of the International AIDS Society · 2021Observational
- Unfilled Prescriptions of Medicare Beneficiaries: Prevalence, Reasons, and Types of Medicines Prescribed.Journal of managed care & specialty pharmacy · 2020Article
- Examining adherence barriers among women with HIV to tailor outreach for long-acting injectable antiretroviral therapy.BMC women's health · 2020Article
- A Behavioral Adherence Intervention Improves Rates of Viral Suppression Among Adherence-Challenged People Living with HIV in South India.AIDS and behavior · 2020Article
- The Health and Sociocultural Correlates of AIDS Genocidal Beliefs and Medical Mistrust Among African American MSM.AIDS and behavior · 2018Article
- An Exploration of Syndemic Factors That Influence Engagement in HIV Care Among Black Men.Qualitative health research · 2018Article
- "It's Almost Like a Crab-in-a-Barrel Situation": Stigma, Social Support, and Engagement in Care Among Black Men Living With HIV.AIDS education and prevention : official publication of the International Society for AIDS Education · 2018Article
- The effect of socioeconomic disadvantage on strategies to end the AIDS epidemic.The Lancet. Public health · 2016Article
- Risk Factors for Loss to Follow-Up among People Who Inject Drugs in a Risk Reduction Program at Karachi, Pakistan. A Case-Cohort Study.PloS one · 2016Article
- Antiretroviral Regimen Durability and Success in Treatment-Naive and Treatment-Experienced Patients by Year of Treatment Initiation, United States, 1996-2011.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Appreciating Reasons for Nonadherence in Women.Health care for women international · 2015Article
- Implementation challenges for long-acting antivirals as treatment.Current opinion in HIV and AIDS · 2015Review
- Factors associated with high transmission risk and detectable plasma HIV RNA in HIV-infected MSM on ART.International journal of STD & AIDS · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNonadherence to antiretroviral therapy (ARVT) is an important behavioral determinant of the success of ARVT. Nonadherence may lead to virological failure, and increases the risk of development of drug resistance. Understanding the prevalence of nonadherence and associated factors is important to inform secondary HIV prevention efforts. METHODOLOGY/PRINCIPAL
findingsWe used data from a cross-sectional interview study of persons with HIV conducted in 18 U.S. states from 2000-2004. We calculated the proportion of nonadherent respondents (took <95% of prescribed doses in the past 48 hours), and the proportion of doses missed. We used multivariate logistic regression to describe factors associated with nonadherence. Nine hundred and fifty-eight (16%) of 5,887 respondents reported nonadherence. Nonadherence was significantly (p<0.05) associated with black race and Hispanic ethnicity; age <40 years; alcohol or crack use in the prior 12 months; being prescribed >or=4 medications; living in a shelter or on the street; and feeling "blue" >or=14 of the past 30 days. We found weaker associations with having both male-male sex and injection drug use risks for HIV acquisition; being prescribed ARVT for >or=21 months; and being prescribed a protease inhibitor (PI)-based regimen not boosted with ritonavir. The median proportion of doses missed was 50%. The most common reasons for missing doses were forgetting and side effects. CONCLUSIONS/SIGNIFICANCE: Self-reported recent nonadherence was high in our study. Our data support increased emphasis on adherence in clinical settings, and additional research on how providers and patients can overcome barriers to adherence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.