ArticleBritish journal of cancer2007
Development of IFN-gamma resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells.
Article in British journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Resistance to the proapoptotic effects of interferon-gamma on melanoma cells used in patient-specific dendritic cell immunotherapy is associated with improved overall survival.Cancer immunology, immunotherapy : CII · 2011Trial
- Interferons and Resistance Mechanisms in Tumors and Pathogen-Driven Diseases-Focus on the Major Histocompatibility Complex (MHC) Antigen Processing Pathway.International journal of molecular sciences · 2023Review
- SOCS3 gene silencing does not occur through methylation and mutations in gastric cancer.Human cell · 2022Article
- Construction of immunotherapy-related prognostic gene signature and small molecule drug prediction for cutaneous melanoma.Frontiers in oncology · 2022Article
- IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells.Journal of experimental & clinical cancer research : CR · 2017Article
- Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment.Frontiers in immunology · 2017Review
- Tetraspanin CD37 protects against the development of B cell lymphoma.The Journal of clinical investigation · 2016Article
- Tumour-promoting role of SOCS1 in colorectal cancer cells.Scientific reports · 2015Article
- Article
- Low expression of SOCS-1 and SOCS-3 is a poor prognostic indicator for gastric cancer patients.Journal of cancer research and clinical oncology · 2015Article
- Short peptide type I interferon mimetics: therapeutics for experimental allergic encephalomyelitis, melanoma, and viral infections.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2014Article
- Autoimmunity as a double agent in tumor killing and cancer promotion.Frontiers in immunology · 2014Review
- SOCS, inflammation, and cancer.JAK-STAT · 2013Review
- Role of SOCS-1 Gene on Melanoma Cell Growth and Tumor Development.Translational oncology · 2011Article
- Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells.BMC cancer · 2010Article
- Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Article
- Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells.Cancer science · 2008Article
- Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas.Molecular cancer research : MCR · 2008Review
- Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors.Cancer research · 2008Article
- IFN inducibility of major histocompatibility antigens in tumors.Advances in cancer research · 2008Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The resistance to interferons (IFNs) limits their anticancer therapeutic efficacy. Here we studied the evolution of an IFN-resistant state in vitro using melanoma cell lines. We found that the cells became less sensitive to antiproliferative effect of IFN-gamma after prolonged cultivation enabling us to isolate sensitive and resistant subclones of the parental line. We investigated transcription of signal transducer and activator of transcription (STAT) 1-6 and suppressor of cytokine signalling (SOCS) 1-3 genes, and phosphorylation of STAT 1 protein. The resistant subline (termed WM 1158R) differed from the sensitive subline (WM 1158S) by a constitutive expression of SOCS 3, lack or weak SOCS 1-3 activation following IFN-gamma, and short duration of cytokine activatory signal. Similar correlations were observed in additional melanoma lines differing in IFN sensitivities. At the protein level, IFN-gamma induced strong and prolonged STAT 1 activation at serine 727 (S727) in WM 1158R while in WM 1158S cells phosphorylation of this amino acid was much less pronounced. On the other hand, phosphorylation of tyrosine 701 (Y701) was stimulated regardless of the sensitivity phenotype. In conclusion, constitutive expression of SOCS 3 is correlated with attenuation of its induction following IFN treatment. These results suggest that progression of melanoma cells from IFN sensitivity to IFN insensitivity associates with changes in SOCS expression.
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