ArticleMolecular psychiatry2007
Association and linkage of allelic variants of the dopamine transporter gene in ADHD.
Article in Molecular psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Association study and a systematic meta-analysis of the VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention-deficit hyperactivity disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2019Pooled it
- Candidate gene studies of ADHD: a meta-analytic review.Human genetics · 2009Pooled it
- Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Pooled it
- Polymorphisms in dopamine transporter (SLC6A3) are associated with stimulant effects of D-amphetamine: an exploratory pharmacogenetic study using healthy volunteers.Behavior genetics · 2010Trial
- Adrenergic alpha2A receptor gene and response to methylphenidate in attention-deficit/hyperactivity disorder-predominantly inattentive type.Journal of neural transmission (Vienna, Austria : 1996) · 2008Trial
- The Use ofBiomedicines · 2022Review
- No Influence of Dopamine System Gene Variations on Acute Effects of MDMA.Frontiers in psychiatry · 2019Article
- Comorbidity of Internet use disorder and attention deficit hyperactivity disorder: Two adult case-control studies.Journal of behavioral addictions · 2017Article
- Analysis of shared homozygosity regions in Saudi siblings with attention deficit hyperactivity disorder.Psychiatric genetics · 2017Article
- Genetic associations with reflexive visual attention in infancy and childhood.Developmental science · 2017Article
- Dopamine transporter gene may be associated with bipolar disorder and its personality traits.European archives of psychiatry and clinical neuroscience · 2015Article
- Article
- Biomarkers in the diagnosis of ADHD--promising directions.Current psychiatry reports · 2014Review
- The neurobiological link between OCD and ADHD.Attention deficit and hyperactivity disorders · 2014Review
- Genetic factors modulating the response to stimulant drugs in humans.Current topics in behavioral neurosciences · 2012Review
- Drug therapy of attention deficit hyperactivity disorder: current trends.Mens sana monographs · 2012Article
- Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree.Molecular psychiatry · 2011Article
- Monoamine transporters: vulnerable and vital doorkeepers.Progress in molecular biology and translational science · 2011Review
- Toward a better understanding of ADHD: LPHN3 gene variants and the susceptibility to develop ADHD.Attention deficit and hyperactivity disorders · 2010Review
- Does the difference between physically active and couch potato lie in the dopamine system?International journal of biological sciences · 2010Review
Corrections and comments
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Authors and funding
26 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously, we had reported a genome-wide scan for attention-deficit/hyperactivity disorder (ADHD) in 102 families with affected sibs of German ancestry; the highest multipoint LOD score of 4.75 was obtained on chromosome 5p13 (parametric HLOD analysis under a dominant model) near the dopamine transporter gene (DAT1). We genotyped 30 single nucleotide polymorphisms (SNPs) in this candidate gene and its 5' region in 329 families (including the 102 initial families) with 523 affected offspring. We found that (1) SNP rs463379 was significantly associated with ADHD upon correction for multiple testing (P=0.0046); (2) the global P-value for association of haplotypes was significant for block two upon correction for all (n=3) tested blocks (P=0.0048); (3) within block two we detected a nominal P=0.000034 for one specific marker combination. This CGC haplotype showed relative risks of 1.95 and 2.43 for heterozygous and homozygous carriers, respectively; and (4) finally, our linkage data and the genotype-IBD sharing test (GIST) suggest that genetic variation at the DAT1 locus explains our linkage peak and that rs463379 (P<0.05) is the only SNP of the above haplotype that contributed to the linkage signal. In sum, we have accumulated evidence that genetic variation at the DAT1 locus underlies our ADHD linkage peak on chromosome 5; additionally solid association for a single SNP and a haplotype were shown. Future studies are required to assess if variation at this locus also explains other positive linkage results obtained for chromosome 5p.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.