ArticleMolecular psychiatry2008
Genome-wide linkage scan for nicotine dependence in European Americans and its converging results with African Americans in the Mid-South Tobacco Family sample.
Article in Molecular psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Meta-analysis of 15 genome-wide linkage scans of smoking behavior.Biological psychiatry · 2010Pooled it
- Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Trial
- Similarities and dissimilarities between psychiatric cluster disorders.Molecular psychiatry · 2021Article
- Roma Socioeconomic Status Has a Higher Impact on Smoking Behaviour than Genetic Susceptibility.International journal of environmental research and public health · 2021Article
- Wastewater-based epidemiology in low Human Development Index states: bias in consumption monitoring of illicit drugs.Environmental science and pollution research international · 2018Review
- Detecting Gene-Gene Interactions Associated with Multiple Complex Traits with U-Statistics.Current genomics · 2016Article
- Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.Molecular psychiatry · 2016Review
- The contribution of rare and common variants in 30 genes to risk nicotine dependence.Molecular psychiatry · 2015Article
- Identification of CHRNA5 rare variants in African-American heavy smokers.Psychiatric genetics · 2014Article
- Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants.Molecular neurobiology · 2014Review
- Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Article
- Genetics of GABAergic signaling in nicotine and alcohol dependence.Human genetics · 2012Review
- Evaluation of the brief wisconsin inventory of smoking dependence motives in african-american and European-american heavy smokers.Frontiers in psychiatry · 2012Article
- Linkage analyses of stimulant dependence, craving, and heavy use in American Indians.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- A genomewide linkage scan of cocaine dependence and major depressive episode in two populations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Linkage scan of nicotine dependence in the University of California, San Francisco (UCSF) Family Alcoholism Study.Psychological medicine · 2011Article
- Genome-wide scan for self-rating of the effects of alcohol in American Indians.Psychiatric genetics · 2010Article
- Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Replication and extension of association of choline acetyltransferase with nicotine dependence in European and African American smokers.Human genetics · 2010Article
- Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Previously, we reported a genome-wide scan for nicotine dependence (ND) in the African American (AA) sample of the Mid-South Tobacco Family (MSTF) cohort. In this study, we conducted a genome-wide scan in 629 individuals representing 200 nuclear families of European American (EA) origin of the MSTF cohort with the goals of identifying vulnerability loci for ND in the EAs and determining converging regions across the ethnic groups. We examined 385 autosomal microsatellite markers for ND, which was assessed by smoking quantity (SQ), the Heaviness of Smoking Index (HSI) and the Fagerström test for ND (FTND). After performing linkage analyses using various methods implemented in the GENEHUNTER and SAGE programs, we found eight regions on chromosomes 2, 4, 9-12, 17 and 18 that met the criteria for suggestive linkage to at least one ND measure in the EA sample. Of these, the region on chromosome 4 at 43 cM showed suggestive linkage to indexed SQ, the HSI and the FTND, and the region on chromosome 9 at 24 cM showed suggestive linkage to the HSI and the FTND. To increase detection power, we analyzed a combined AA and EA sample using age, gender and ethnicity as covariates and found that the region on chromosome 12 near marker D12S372 showed significant linkage to SQ. Additionally, we found six regions on chromosomes 9-11, 13 and 18 that showed suggestive linkage to at least one ND measure in the combined sample. When we compared the linkage peaks detected for ND among the two samples and a combined sample, we found that four regions on chromosomes 9 (two regions), 11 and 18 overlapped. On the other hand, we identified five regions on chromosomes 2, 4, 10, 12 and 17 that showed linkage to ND only in the EA sample, and two regions on chromosomes 10 and 13 that showed linkage to ND only in the AA sample. For those linkages identified in only one sample, we found that the combined analysis of AA plus EA samples actually decreased the linkage signal. This indicates that some chromosomal regions may be more homogenous than others across the ethnic samples. All regions except for the one on chromosome 12 have been detected at nominally significant levels in other studies, providing independent replication of ND loci in different populations.
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