ArticlePLoS biology2007
A new approach for using genome scans to detect recent positive selection in the human genome.
Article in PLoS biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 263 papers, 1 of them a synthesis that pooled it.
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Who cites it
263 citing papers in PubMed, 1 synthesis or guideline pooled it, 530 citations in OpenAlex.
- A Meta-Assembly of Selection Signatures in Cattle.PloS one · 2016Pooled it
- Population Differentiation and Polygenic Selection in the Finnish Ayrshire Cows Selected on Genomic Information.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Identification of two genomic cryptotypes of Plasmodium malariae in Africa.PLoS neglected tropical diseases · 2026Article
- Bringing environment back into human evolution: why human genetics needs genome-environment association studies.Human genetics · 2026Review
- Genomic Insights Into Host Shifts BetweenEvolutionary applications · 2026Article
- Refining selection signals in dairy sheep using high-density genotyping data.Journal of animal science · 2026Article
- Bovine Genome Database: new curated collection of selective sweeps in bovine populations across the world.Nucleic acids research · 2026Article
- Genome-wide analysis of genetic diversity in Anopheles darlingi from Rondônia State, Brazil.Communications biology · 2025Article
- Genomic evidence of positive selection highlights functional divergence associated with environmental resilience in central and West African indigenous cattle.Scientific reports · 2025Article
- Signals of Ancestry-Specific Selection in Gentle Africanized Honey Bees.Genome biology and evolution · 2025Article
- Comparative detection of selection signatures in indigenous and crossbred Turkish sheep breeds.Scientific reports · 2025Article
- Genome-wide identification of selection signatures across altitudinal gradients in dairy sheep breeds.Scientific reports · 2025Article
- Population Genomics Reveals Demographic History and Climate Adaptation in Japanese Arabidopsis halleri.Plant & cell physiology · 2025Article
- Extreme genetic signatures of local adaptation in a notorious rice pest,National science review · 2025Article
- Genome-wide study for signatures of selection identifies genomic regions and candidate genes associated with milk traits in sheep.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Population structure, selection signal and introgression of gamecocks revealed by whole genome sequencing.Journal of animal science and biotechnology · 2025Article
- Genome-wide scans for signatures of selection in North African sheep reveals differentially selected regions between fat- and thin-tailed breeds.Animal genetics · 2025Article
- Genome-wide scan for signatures of selection in Hanwoo and Angus cattle using whole-genome sequence data.PloS one · 2025Article
- Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance.Nature communications · 2024Article
- Candidate selective sweeps in US wheat populations.The plant genome · 2024Article
203 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide scanning for signals of recent positive selection is essential for a comprehensive and systematic understanding of human adaptation. Here, we present a genomic survey of recent local selective sweeps, especially aimed at those nearly or recently completed. A novel approach was developed for such signals, based on contrasting the extended haplotype homozygosity (EHH) profiles between populations. We applied this method to the genome single nucleotide polymorphism (SNP) data of both the International HapMap Project and Perlegen Sciences, and detected widespread signals of recent local selection across the genome, consisting of both complete and partial sweeps. A challenging problem of genomic scans of recent positive selection is to clearly distinguish selection from neutral effects, given the high sensitivity of the test statistics to departures from neutral demographic assumptions and the lack of a single, accurate neutral model of human history. We therefore developed a new procedure that is robust across a wide range of demographic and ascertainment models, one that indicates that certain portions of the genome clearly depart from neutrality. Simulations of positive selection showed that our tests have high power towards strong selection sweeps that have undergone fixation. Gene ontology analysis of the candidate regions revealed several new functional groups that might help explain some important interpopulation differences in phenotypic traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.