ArticleProceedings of the National Academy of Sciences of the United States of America2007
Amyloidogenic potential of foie gras.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed.
- Amyloid A amyloidosis associated with Streptococcus suis infection in a young commercial pig with wild-type serum amyloid A.Veterinary research communications · 2025Article
- Surveillance of amyloid A deposits in commercial beef liver and assessment of food hygiene risks.The Journal of veterinary medical science · 2025Article
- The Promising Role of Selenium and Yeast in the Fight Against Protein Amyloidosis.Biological trace element research · 2025Review
- Deactivation of the Unfolded Protein Response Aggravated Renal AA Amyloidosis in HSF1 Deficiency Mice.Molecular and cellular biology · 2024Article
- Food protein-derived amyloids do not accelerate amyloid β aggregation.Scientific reports · 2023Article
- The worldwide need for amyloid diagnosis in animals.Journal of biosciences · 2023Article
- The first report of polymorphisms of the prion protein gene (Frontiers in veterinary science · 2023Article
- Health concerns about possible long-term effects of legally marketed milk and dairy from animals with intramammary infections.Frontiers in public health · 2023Article
- SAA fibrils involved in AA amyloidosis are similar in bulk and by single particle reconstitution: A MAS solid-state NMR study.Journal of structural biology: X · 2022Article
- Species-barrier on the cross-species oral transmission of bovine AA amyloidosis in mice.The Journal of veterinary medical science · 2021Article
- Oxazolone-induced gastrointestinal disorders enhance the oral transmission of AA amyloidosis in mice.The Journal of veterinary medical science · 2021Article
- Article
- p53, A Victim of the Prion Fashion.Cancers · 2021Review
- Embryonic cuticle from artemia cyst shell displays amyloid-like characteristics and nontoxicity after oral consumption.Journal of biosciences · 2021Article
- Cross-Species and Cross-Polymorph Seeding of Lysozyme Amyloid Reveals a Dominant Polymorph.Frontiers in molecular biosciences · 2020Article
- Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Proteins: Consequences for Amyloid Formation in Parkinson's Disease.Journal of Parkinson's disease · 2020Review
- Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids.Nature communications · 2019Article
- A new era for understanding amyloid structures and disease.Nature reviews. Molecular cell biology · 2018Review
- Noncerebral Amyloidoses: Aspects on Seeding, Cross-Seeding, and Transmission.Cold Spring Harbor perspectives in medicine · 2018Review
- Post mortem findings and their relation to AA amyloidosis in free-ranging Herring gulls (Larus argentatus).PloS one · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The human cerebral and systemic amyloidoses and prion-associated spongiform encephalopathies are acquired or inherited protein folding disorders in which normally soluble proteins or peptides are converted into fibrillar aggregates. This is a nucleation-dependent process that can be initiated or accelerated by fibril seeds formed from homologous or heterologous amyloidogenic precursors that serve as an amyloid enhancing factor (AEF) and has pathogenic significance in that disease may be transmitted by oral ingestion or parenteral administration of these conformationally altered components. Except for infected brain tissue, specific dietary sources of AEF have not been identified. Here we report that commercially available duck- or goose-derived foie gras contains birefringent congophilic fibrillar material composed of serum amyloid A-related protein that acted as a potent AEF in a transgenic murine model of secondary (amyloid A protein) amyloidosis. When such mice were injected with or fed amyloid extracted from foie gras, the animals developed extensive systemic pathological deposits. These experimental data provide evidence that an amyloid-containing food product hastened the development of amyloid protein A amyloidosis in a susceptible population. On this basis, we posit that this and perhaps other forms of amyloidosis may be transmissible, akin to the infectious nature of prion-related illnesses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.