ArticleProceedings of the National Academy of Sciences of the United States of America2007
Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Who cites it
41 citing papers in PubMed, 54 citations in OpenAlex.
- Tiantan vaccinia virus-based vaccine with promising safety provides sustained protection against mpox in non-human primates.Nature communications · 2025Article
- Viral Infection and Dissemination Through the Lymphatic System.Microorganisms · 2025Review
- Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node.Cellular & molecular immunology · 2024Review
- mRNA-LNP vaccine-induced CD8Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Monkeypox virus quadrivalent mRNA vaccine induces immune response and protects against vaccinia virus.Signal transduction and targeted therapy · 2023Article
- Orthopoxvirus Zoonoses-Do We Still Remember and Are Ready to Fight?Pathogens (Basel, Switzerland) · 2023Review
- Article
- The role and uses of antibodies in COVID-19 infections: a living review.Oxford open immunology · 2021Review
- Engineering antibody-based molecules for HIV treatment and cure.Current opinion in HIV and AIDS · 2020Review
- Loss of Resistance to Mousepox during Chronic Lymphocytic Choriomeningitis Virus Infection Is Associated with Impaired T-Cell Responses and Can Be Rescued by Immunization.Journal of virology · 2020Article
- Langerhans Cells Orchestrate the Protective Antiviral Innate Immune Response in the Lymph Node.Cell reports · 2019Article
- Aging of Antiviral CD8Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node.Cell reports · 2018Article
- Cutting Edge: Protection by Antiviral Memory CD8 T Cells Requires Rapidly Produced Antigen in Large Amounts.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Tissue reservoirs of antiviral T cell immunity in persistent human CMV infection.The Journal of experimental medicine · 2017Article
- Protective CD8+ T cell memory without help.Oncotarget · 2015Article
- Redundant Function of Plasmacytoid and Conventional Dendritic Cells Is Required To Survive a Natural Virus Infection.Journal of virology · 2015Article
- CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization.Journal of virology · 2015Article
- T cell-mediated immune response to respiratory coronaviruses.Immunologic research · 2014Review
- Epithelial immunization induces polyfunctional CD8+ T cells and optimal mousepox protection.Journal of virology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
It is uncertain how immunity protects against systemic viral diseases. Here, we demonstrate that in the absence of persistent virus, not only antibodies but also recall responses by long-lived memory CD8(+) T cells prevent mousepox, a disease caused by ectromelia virus, a close relative of the virus of human smallpox. Moreover, we show that to protect, recall CD8(+) T cells directly kill targets in the lymph node draining the primary site of infection thus curbing systemic viral spread. Therefore, our work provides the basis for a model where lymph nodes are not just organs where lymphocytes become activated and proliferate but also the sites where a major fight against virus spread takes place.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.