ArticleChinese medicine2007
Simultaneous determination of multiple marker constituents in concentrated Gegen Tang granule by high performance liquid chromatography.
Article in Chinese medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Progress in Traditional Chinese Medicine Against Respiratory Viruses: A Review.Frontiers in pharmacology · 2021Review
- Exploration of the mechanisms of Ge Gen Decoction against influenza A virus infection.Chinese journal of natural medicines · 2019Article
- Simultaneous determination of five marker constituents in Ssanghwa tang by HPLC/DAD.Pharmacognosy magazine · 2010Article
- Chinese Medicine (CM) matters.Chinese medicine · 2008Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConcentrated Gegen Tang (GT) granule is a widely available traditional Chinese medicinal product for the treatment of cold and flu. There was no reliable analytical method available for the quality assessment of GT granules.
methodsAn HPLC method with an Agilent Zorbax SB-Phenyl Stablebond column (250 x 4.6 mm, 5 microm) was developed and validated. The mobile phase gradient was a mixture of 0.1% trifluoroacetic acid (TFA) in acetonitrile (ACN) and 0.1% TFA in water. The detection with a diode-array detector was set at 207, 230, 250 and 275 nm. Seven components, namely puerarin, daidzein, paeoniflorin, cinnamic acid, glycyrrhizin, ephedrine and pseudoephedrine were selected as marker compounds for the evaluation.
resultsThe regression equations revealed good linear relationships (correlation coefficients: 0.9994-0.9998) between the peak areas and concentrations. The recovery was between 98.8% and 101.7% with good precision and accuracy. The quality of GT granule from four different manufacturers was evaluated with this newly developed method. Samples from four manufacturers showed similar profiles but contents of the detected markers varied significantly among manufacturers and batches.
conclusionA new method using high performance liquid chromatography (HPLC) has been developed for simple and reliable quality control of commercial concentrated GT granules. Sensitivity was increased by multi-wavelength detection. The contents of selected marker components in GT granules varied significantly among manufacturers and batches, making it necessary to evaluate the quality of concentrated GT granules in the market.
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