ArticleAging cell2007
Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi.
Article in Aging cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 81 citations in OpenAlex.
- SWI/SNF Chromatin Remodeling Enzymes in Melanoma.Epigenomes · 2022Review
- Article
- From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs.EMBO molecular medicine · 2019Review
- A pH probe inhibits senescence in mesenchymal stem cells.Stem cell research & therapy · 2018Article
- Review
- BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation.Nucleic acids research · 2017Article
- Epigenetic Regulation of Cellular Senescence and Aging.Frontiers in genetics · 2017Review
- The Immortal Senescence.Methods in molecular biology (Clifton, N.J.) · 2017Review
- p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.Nature medicine · 2016Article
- Histone Deacetylases Inhibitors in the Treatment of Retinal Degenerative Diseases: Overview and Perspectives.Journal of ophthalmology · 2015Review
- Modulation of Brahma expression by the mitogen-activated protein kinase/extracellular signal regulated kinase pathway is associated with changes in melanoma proliferation.Archives of biochemistry and biophysics · 2014Article
- Expression of proteins involved in epigenetic regulation in human cutaneous melanoma and peritumoral skin.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Article
- Epigenetic regulation of cardiac myocyte differentiation.Frontiers in genetics · 2014Review
- MITF-independent pro-survival role of BRG1-containing SWI/SNF complex in melanoma cells.PloS one · 2013Article
- The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish.PloS one · 2013Article
- Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers.Cancer biology & therapy · 2012Review
- A prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell lines.Pigment cell & melanoma research · 2012Article
- Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.The EMBO journal · 2012Article
- HDAC1 regulates fear extinction in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The retinoblastoma (RB)/p16(INK4a) pathway regulates senescence of human melanocytes in culture and oncogene-induced senescence of melanocytic nevi in vivo. This senescence response is likely due to chromatin modifications because RB complexes from senescent melanocytes contain increased levels of histone deacetylase (HDAC) activity and tethered HDAC1. Here we show that HDAC1 is prominently detected in p16(INK4a)-positive, senescent intradermal melanocytic nevi but not in proliferating, recurrent nevus cells that localize to the epidermal/dermal junction. To assess the role of HDAC1 in the senescence of melanocytes and nevi, we used tetracycline-based inducible expression systems in cultured melanocytic cells. We found that HDAC1 drives a sequential and cooperative activity of chromatin remodeling effectors, including transient recruitment of Brahma (Brm1) into RB/HDAC1 mega-complexes, formation of heterochromatin protein 1 beta (HP1 beta)/SUV39H1 foci, methylation of H3-K9, stable association of RB with chromatin and significant global heterochromatinization. These chromatin changes coincide with expression of typical markers of senescence, including the senescent-associated beta-galactosidase marker. Notably, formation of RB/HP1 beta foci and early tethering of RB to chromatin depends on intact Brm1 ATPase activity. As cells reached senescence, ejection of Brm1 from chromatin coincided with its dissociation from HP1 beta/RB and relocalization to protein complexes of lower molecular weight. These results provide new insights into the role of the RB pathway in regulating cellular senescence and implicate HDAC1 as a likely mediator of early chromatin remodeling events.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.