ArticleAging cell2007
Long-lived dwarf mice: are bile acids a longevity signal?
Article in Aging cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Acarbose improves health and lifespan in aging HET3 mice.Aging cell · 2019Article
- Article
- Empirical Validation of a Hypothesis of the Hormetic Selective Forces Driving the Evolution of Longevity Regulation Mechanisms.Frontiers in genetics · 2016Article
- Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid.International journal of molecular sciences · 2014Review
- Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.Aging cell · 2014Article
- A photocleavable masked nuclear-receptor ligand enables temporal control of C. elegans development.Angewandte Chemie (International ed. in English) · 2014Article
- Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes.American journal of physiology. Endocrinology and metabolism · 2013Article
- Chronic caloric restriction partially protects against age-related alteration in serum metabolome.Age (Dordrecht, Netherlands) · 2013Article
- Interspecies Chemical Signals Released into the Environment May Create Xenohormetic, Hormetic and Cytostatic Selective Forces that Drive the Ecosystemic Evolution of Longevity Regulation Mechanisms.Dose-response : a publication of International Hormesis Society · 2012Article
- Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level.Aging · 2010Article
- Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathways that control aging act via regulated biochemical processes, among which metabolism of xenobiotics (potentially harmful chemical agents encountered as environmental toxicants, for example, drugs, or produced internally) is one possible candidate. A new study of long-lived Ghrhr mutant mice reports that increased bile acid levels activate xenobiotic metabolism via the nuclear receptor, farnesoid X receptor. This increases resistance to xenobiotic stress, possibly contributing to longevity.
Indexed as
Identifiers
17578511What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.