SynthesisMaternal and child health journal2008
Association between maternal infections and preeclampsia: a systematic review of epidemiologic studies.
Synthesis in Maternal and child health journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03305991 (The Role of Maternal TB Infection for Adverse Pregnancy and Infant Health Outcomes in Ethiopia - a Long-term Prospective Cohort Study), which is not on this map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Maternal TB Infection for Adverse Pregnancy and Infant Health Outcomes in Ethiopia - a Long-term Prospective Cohort Study
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Occupational Risk Factors and Hypertensive Disorders in Pregnancy: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Associations of meteorology with adverse pregnancy outcomes: a systematic review of preeclampsia, preterm birth and birth weight.International journal of environmental research and public health · 2013Pooled it
- A prospective study of respiratory viral infection in pregnant women with and without asthma.Chest · 2013Trial
- The Immunopathology of Preeclampsia.Biomedicines · 2026Review
- COVID-19 vaccination status during pregnancy and preeclampsia risk: the pandemic-era cohort of the INTERCOVID consortium.EClinicalMedicine · 2026Article
- Immune Cells in Preeclampsia.International journal of molecular sciences · 2025Review
- Latent toxoplasmosis and preeclampsia: evidence for the role of chronic infection in pregnancy complications.BMC pregnancy and childbirth · 2025Article
- Deep metagenomic characterization of the gut virome in pregnant women with preeclampsia.mSphere · 2024Article
- Adverse Pregnancy Outcomes and Maternal Periodontal Disease: An Overview on Meta-Analytic and Methodological Quality.Journal of clinical medicine · 2023Review
- Gestational Antibodies to C. pneumoniae, H. pylori and CMV in Women with Preeclampsia and in Matched Controls.Maternal and child health journal · 2022Article
- Interleukin-17 promotes proliferation, migration, and invasion of trophoblasts via regulating PPAR-γ/RXR-α/Wnt signaling.Bioengineered · 2022Article
- The function and mechanism of action of uterine microecology in pregnancy immunity and its complications.Frontiers in cellular and infection microbiology · 2022Review
- Role of Periodontal Bacteria, Viruses, and PlacentalCurrent issues in molecular biology · 2021Article
- Falciparum but not vivax malaria increases the risk of hypertensive disorders of pregnancy in women followed prospectively from the first trimester.BMC medicine · 2021Article
- A Multi-Objective Approach for Drug Repurposing in Preeclampsia.Molecules (Basel, Switzerland) · 2021Article
- Maternal Serum Cytokine Concentrations in Healthy Pregnancy and Preeclampsia.Journal of pregnancy · 2021Review
- Review
- Focus on the Gut-Kidney Axis in Health and Disease.Frontiers in medicine · 2020Review
- Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring.Journal of clinical medicine · 2019Review
- Research Recommendations From the National Institutes of Health Workshop on Predicting, Preventing, and Treating Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesA growing body of evidence suggests an association between maternal infection and preeclampsia. To examine the strength of this association, we conducted a comprehensive review of studies published in peer-reviewed journals.
methodsData collection for this review involved Medline, Embase, and Cochrane data base searches of published studies since 1964 on the relationship between maternal infection and preeclampsia. Data were abstracted according to predefined inclusion and exclusion criteria. Study population included women with preeclampsia and normotensive mothers with and without bacterial or viral infections. Altogether, thirty two original studies were identified and evaluated for methodological quality, preeclampsia diagnosis and adjustment for well-known preeclampsia confounders. Pooled odds ratios and 95% confidence intervals, according to infection status, were calculated using DerSimonian-Laird random-effects models. Publication bias was assessed with a funnel plot and Egger's regression asymmetry test.
resultsSixteen of the 32 studies evaluated were selected for inclusion in the meta-analysis. These studies showed that women with either a bacterial or viral infection were at higher risk of developing preeclampsia, compared to women without infection. Combined results for the 16 studies yielded an OR of 2.1 (95% CI 1.6-2.7). Separate pooled estimates for prospective (OR 2.3, 95% CI 1.7-3.0), case control and retrospective studies combined (OR 2.0, 95% CI 1.4-2.9) yielded similar results. Heterogeneity was significant across overall pooled estimates, case control and retrospective studies (Q(df=20) of 45.7, P = .001; Q(df=10) of 38.7, P < .005, respectively), but not prospective studies (Q(df=9) of 6.5 P = .69).
conclusionsIn our analysis, any infection (bacterial or viral) was associated with a two-fold higher risk of preeclampsia. This association may provide a potential explanation for preeclampsia-related inflammation.
Indexed as
Identifiers
17577649What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.