ArticleProceedings of the National Academy of Sciences of the United States of America2007
p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 95 citations in OpenAlex.
- Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations.NPJ precision oncology · 2024Article
- A complex of cadherin 17 with desmocollin 1 and p120-catenin regulates colorectal cancer migration and invasion according to the cell phenotype.Journal of experimental & clinical cancer research : CR · 2024Article
- Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice.BMC developmental biology · 2020Article
- Cortactin function in invadopodia.Small GTPases · 2020Review
- Podosome formation impairs endothelial barrier function by sequestering zonula occludens proteins.Journal of cellular physiology · 2020Article
- Epithelial-specific isoforms of protein 4.1R promote adherens junction assembly in maturing epithelia.The Journal of biological chemistry · 2020Article
- Control of Podocyte and Glomerular Capillary Wall Structure and Elasticity by WNK1 Kinase.Frontiers in cell and developmental biology · 2020Article
- The regulation of junctional actin dynamics by cell adhesion receptors.Histochemistry and cell biology · 2018Review
- Gold Nanorod Photothermal Therapy Alters Cell Junctions and Actin Network in Inhibiting Cancer Cell Collective Migration.ACS nano · 2018Article
- Spontaneous reactivation of latent HIV-1 promoters is linked to the cell cycle as revealed by a genetic-insulators-containing dual-fluorescence HIV-1-based vector.Scientific reports · 2018Article
- p120-catenin is required for regulating epidermal proliferation, differentiation, and barrier function.Journal of cellular physiology · 2018Article
- Cortactin deficiency causes increased RhoA/ROCK1-dependent actomyosin contractility, intestinal epithelial barrier dysfunction, and disproportionately severe DSS-induced colitis.Mucosal immunology · 2017Article
- 15-Deoxy-ΔOncology letters · 2017Article
- Cadherin-11 localizes to focal adhesions and promotes cell-substrate adhesion.Nature communications · 2016Article
- Cadherin-11 coordinates cellular migration and extracellular matrix remodeling during aortic valve maturation.Developmental biology · 2015Article
- Actin remodeling by Nck regulates endothelial lumen formation.Molecular biology of the cell · 2015Article
- Systems biology approach to studying proliferation-dependent prognostic subnetworks in breast cancer.Scientific reports · 2015Article
- Protein interactions of cortactin in relation to invadopodia formation in metastatic renal clear cell carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Mechanisms of endothelial cell migration.Cellular and molecular life sciences : CMLS · 2014Review
- SRChing for the substrates of Src.Oncogene · 2014Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The armadillo-family protein, p120 catenin (p120), binds to the juxtamembrane domain of classical cadherins and increases cell-cell junction stability. Overexpression of p120 modulates the activity of Rho family GTPases and augments cell migratory ability. Here we show that down-regulation of p120 in epithelial MCF-7 cells by siRNA leads to a striking decrease in lamellipodial persistence and focal adhesion formation. Similar alterations in lamellipodial activity were observed in MCF-7 cells treated with siRNA to cortactin, an activator of Arp2/3-dependent actin polymerization. We found that, in many cell types, p120 is colocalized with cortactin-containing actin structures not only at cell-cell junctions, but also at extrajunctional sites including membrane ruffles and actin-rich halos around endocytotic vesicles. p120 depletion led to dramatic loss of cortactin and its partner, Arp3, from the cell leading edges. Cortactin and p120 are shown to directly interact with each other via the cortactin N-terminal region. We propose that the mechanism underlying p120 functions at the leading edge involves its cooperation with cortactin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.