ArticleThe Journal of cell biology2007
Organization of chromatin and histone modifications at a transcription site.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Sequence Conservation and Functional Significance of Charged Clusters in Mitochondria-Located Proteins of Green Plants.Journal of molecular evolution · 2026Article
- The role of transcription bodies in gene expression: what embryos teach us.Biochemical Society transactions · 2025Review
- Perichromatin region: a moveable feast.Histochemistry and cell biology · 2018Review
- Nucleolar DNA: the host and the guests.Histochemistry and cell biology · 2016Review
- Dynamic properties of independent chromatin domains measured by correlation spectroscopy in living cells.Epigenetics & chromatin · 2016Article
- Single-molecule analysis of transcription factor binding at transcription sites in live cells.Nature communications · 2014Article
- Co-expressed genes prepositioned in spatial neighborhoods stochastically associate with SC35 speckles and RNA polymerase II factories.Cellular and molecular life sciences : CMLS · 2014Article
- A biophysical model for transcription factories.BMC biophysics · 2013Article
- Transcription factories.Frontiers in genetics · 2012Article
- 3D shortcuts to gene regulation.Current opinion in cell biology · 2010Review
- Single cell analysis of transcriptional activation dynamics.PloS one · 2010Article
- Transcription factories: gene expression in unions?Nature reviews. Genetics · 2009Review
- Glucocorticoid receptor activation of the Ciz1-Lcn2 locus by long range interactions.The Journal of biological chemistry · 2009Article
- Imaging transcription in living cells.Annual review of biophysics · 2009Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
According to the transcription factory model, localized transcription sites composed of immobilized polymerase molecules transcribe chromatin by reeling it through the transcription site and extruding it to form a surrounding domain of recently transcribed decondensed chromatin. Although transcription sites have been identified in various cells, surrounding domains of recently transcribed decondensed chromatin have not. We report evidence that transcription sites associated with a tandem gene array in mouse cells are indeed surrounded by or adjacent to a domain of decondensed chromatin composed of sequences from the gene array. Formation of this decondensed domain requires transcription and topoisomerase IIalpha activity. The decondensed domain is enriched for the trimethyl H3K36 mark that is associated with recently transcribed chromatin in yeast and several mammalian systems. Consistent with this, chromatin immunoprecipitation demonstrates a comparable enrichment of this mark in transcribed sequences at the tandem gene array. These results provide new support for the pol II factory model, in which an immobilized polymerase molecule extrudes decondensed, transcribed sequences into its surroundings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.