ReviewThe Journal of cell biology2007
Myelination: all about Rac 'n' roll.
Review in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Characterization of theFASEB bioAdvances · 2025Article
- Lentivirus-Mediated RNA Interference Targeting RhoA Slacks the Migration, Proliferation, and Myelin Formation of Schwann Cells.Molecular neurobiology · 2017Article
- Article
- An efficient method for dorsal root ganglia neurons purification with a one-time anti-mitotic reagent treatment.PloS one · 2013Article
- Lck tyrosine kinase mediates β1-integrin signalling to regulate Schwann cell migration and myelination.Nature communications · 2013Article
- The atypical Guanine-nucleotide exchange factor, dock7, negatively regulates schwann cell differentiation and myelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Assessing the role of the cadherin/catenin complex at the Schwann cell-axon interface and in the initiation of myelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the development of the peripheral nervous system, Schwann cells select individual axons from a nerve bundle and establish a one-to-one relationship through a process termed "radial sorting". Recent findings identify the Rho family GTPase Rac1 as the downstream effector molecule responsible for process extension and lamellipodia formation in Schwann cells, allowing for proper radial sorting and myelination. These findings begin to shed light on our understanding of the distinct and yet essential molecular mechanisms involved in developmental processes preceding myelination.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.