ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2007
Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 81 citations in OpenAlex.
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- Uncoupling protein 1-driven Cre (bioRxiv : the preprint server for biology · 2023Article
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- Plate-Based Respirometry to Assess Thermal Sensitivity of Zebrafish Embryo BioenergeticsFrontiers in physiology · 2021Article
- Emergent Coordination of the CHKB and CPT1B Genes in Eutherian Mammals: Implications for the Origin of Brown Adipose Tissue.Journal of molecular biology · 2020Article
- Importance of adipocyte browning in the evolution of endothermy.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Thermal sensitivity links to cellular cardiac decline in three spiny lobsters.Scientific reports · 2020Article
- Quantitative analyses of adiposity dynamics in zebrafish.Adipocyte · 2019Article
- Coping with exposure to hypoxia: modifications in stress parameters in gilthead seabream (Sparus aurata) fed spirulina (Arthrospira platensis) and brewer's yeast (Saccharomyces cerevisiae).Fish physiology and biochemistry · 2019Article
- The Impact of Early Human Migration on Brown Adipose Tissue Evolution and Its Relevance to the Modern Obesity Pandemic.Journal of the Endocrine Society · 2019Review
- Insights into the neurochemical signature of the Innervation of Beige Fat.Molecular metabolism · 2018Article
- Electron Density of Adipose Tissues Determined by Phase-Contrast Computed Tomography Provides a Measure for Mitochondrial Density and Fat Content.Frontiers in physiology · 2018Article
- Mitochondrial Proton Leak Compensates for Reduced Oxidative Power during Frequent Hypothermic Events in a Protoendothermic Mammal,Frontiers in physiology · 2017Article
- Non-Mammalian Vertebrates: Distinct Models to Assess the Role of Ion Gradients in Energy Expenditure.Frontiers in endocrinology · 2017Review
- Evolution ofFrontiers in physiology · 2017Article
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- Brown adipose tissue: physiological function and evolutionary significance.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Mammalian uncoupling protein 1 (UCP1) mediates nonshivering thermogenesis in brown adipose tissue. We previously reported on the presence of a UCP1 orthologue in ectothermic fish and observed downregulation of UCP1 gene expression in the liver of the common carp. Neither the function of UCP1, nor the mode of UCP1 activation is known in carp liver mitochondria. Here, we compared the proton conductance at 25 degrees C of liver mitochondria isolated from carp either maintained at 20 degrees C (warm-acclimated, WA) or exposed to 8 degrees C (cold-acclimated, CA) water temperature for 7-10 days. Liver mitochondria from WA carp had higher state four rates of oxygen consumption and greater proton conductance at high membrane potential. Liver mitochondria from WA, but not from CA, carp showed a strong increase in proton conductance when palmitate (or 4-hydroxy-trans-2-nonenal, HNE) was added, and this inducible proton conductance was prevented by addition of GDP. This fatty acid sensitive proton leak is likely due to the expression of UCP1 in the liver of WA carp. The observed biochemical properties of proton leak strongly suggest that carp UCP1 is a functional uncoupling protein with broadly the same activatory and inhibitory characteristics as mammalian UCP1. Significant UCP1 expression was also detected in our previous study in whole brain of the carp. We here observed a twofold increase of UCP1 mRNA in carp brain following cold exposure, suggesting a role of UCP1 in the thermal adaptation of brain metabolism. In situ hybridization located the UCP1 gene expression to the optic tectum responsible for visual system control, the descending trigeminal tract and the solitary tract. Taken together, this study characterises uncoupling protein activity in an ectotherm for the first time.
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