ArticleIntensive care medicine2007
High positive end-expiratory pressure levels promote bacterial translocation in experimental pneumonia.
Article in Intensive care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- High versus low positive end-expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute lung injury and acute respiratory distress syndrome.The Cochrane database of systematic reviews · 2021Pooled it
- Effect of Intraoperative Ventilation Strategies on Postoperative Pulmonary Complications: A Meta-Analysis.Frontiers in surgery · 2021Pooled it
- High versus low positive end-expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute lung injury and acute respiratory distress syndrome.The Cochrane database of systematic reviews · 2013Pooled it
- Mechanical Protective Ventilation: New Paradigms in Thoracic Surgery.Journal of clinical medicine · 2025Review
- A structured narrative review of clinical and experimental studies of the use of different positive end-expiratory pressure levels during thoracic surgery.The clinical respiratory journal · 2022Review
- Postural lung recruitment assessed by lung ultrasound in mechanically ventilated children.Critical ultrasound journal · 2017Article
- Variable ventilation improves pulmonary function and reduces lung damage without increasing bacterial translocation in a rat model of experimental pneumonia.Respiratory research · 2016Article
- Early pneumonia and timing of antibiotic therapy in patients after nontraumatic out-of-hospital cardiac arrest.Critical care (London, England) · 2016Article
- Moderate Peep After Tracheal Lipopolysaccharide Instillation Prevents Inflammation and Modifies the Pattern of Brain Neuronal Activation.Shock (Augusta, Ga.) · 2015Article
- Microbial translocation and infectious diseases: what is the link?International journal of microbiology · 2012Article
- Open lung approach vs acute respiratory distress syndrome network ventilation in experimental acute lung injury.British journal of anaesthesia · 2011Article
- Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema.Intensive care medicine · 2010Article
- Year in review in Intensive Care Medicine, 2007. I. Experimental studies. Clinical studies: brain injury and neurology, renal failure and endocrinology.Intensive care medicine · 2008Review
- Ventilation strategy, recruitment, and pulmonary bacterial translocation: scientific clearance is open!Intensive care medicine · 2007Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA previous study in piglets with experimental pneumonia showed that reducing atelectasis by means of open lung ventilation attenuated bacterial translocation compared to conventional ventilation settings. This study examined the effect of open lung ventilation with higher than necessary positive end-expiratory pressures (PEEP) on bacterial translocation. DESIGN AND
settingProspective animal study in a university-affiliated research laboratory. SUBJECTS: Thirty piglets.
interventionsAnimals were surfactant-depleted by whole-lung lavage and infected with group B streptococci. Thereafter the animals were ventilated for 5 h according to either a conventional ventilation strategy, open lung strategy, or open lung/high-PEEP strategy. Blood samples for blood gas analysis and blood bacterial counts were taken every hour. After 5 h of ventilation surviving animals were killed, and lung colony forming units and lung mechanics parameters were determined.
resultsAll animals in both open lung groups survived but only 30% of those in the conventional ventilation group. Open lung ventilation resulted in significantly less bacterial translocation than either conventional or high-PEEP ventilation. Lung function in the conventional ventilated group was significantly less than in the two open lung groups.
conclusionsThe lowest level of bacterial translocation was observed during optimal ventilation (open lung) which was achieved by using individually tailored settings. Deviation to either side can be harmful, as shown by the increased bacterial translocation during conventional and high-PEEP ventilation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.