SynthesisJournal of neuro-oncology2007
Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid plexus tumors.
Synthesis in Journal of neuro-oncology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 148 citations in OpenAlex.
- Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study.Journal of neuro-oncology · 2009Trial
- Choroid plexus carcinoma: state of the field and emerging directions.Oncogenesis · 2026Review
- Report from the National Pediatric Cancer Foundation - infantile glioma and other non-embryonal central nervous system tumors: evolving molecular advances and current treatment landscape.Frontiers in oncology · 2026Review
- The composition of choroid plexus tumor research: a bibliometric analysis of the 100 most impactful studies to date.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Approaches to Minimise the Neurodevelopmental Impact of Choroid Plexus Carcinoma and Its Treatment.Life (Basel, Switzerland) · 2023Review
- Incidence and survival of choroid plexus tumors in the United States.Neuro-oncology practice · 2023Article
- Primary adult choroid plexus carcinomas: a single-center experience with a systematic review.Frontiers in oncology · 2023Article
- Immunotherapy for Pediatric Brain and Spine Tumors: Current State and Future Directions.Pediatric neurosurgery · 2023Review
- Intracranial Subdural Fluid Accumulation Associated with a Choroid Plexus Carcinoma in a Dog.Veterinary sciences · 2022Article
- Final results of the Choroid Plexus Tumor study CPT-SIOP-2000.Journal of neuro-oncology · 2022Article
- Delayed Recurrence of Choroid Plexus Carcinoma in the Sacral Spinal Cord 17 Years after Its Initial Presentation.NMC case report journal · 2022Article
- Choroid plexus carcinoma in two siblings, with a novel genetic mutation in TP53 - A case report and review of literature.Surgical neurology international · 2022Article
- Choroid plexus carcinoma with leptomeningeal spread in an adult: a case report and review of the literature.Journal of medical case reports · 2021Review
- Choroid plexus carcinoma in an adolescent male: a case report.Journal of medical case reports · 2021Article
- Cerebellopontine Angle Primary Choroid Plexus Carcinoma Present in an Adult: Case Report and Literature Review.Cureus · 2021Article
- Pediatric Case of Li-Fraumeni Syndrome in Honduras.Case reports in pediatrics · 2021Article
- Intraventricular choroid plexus tumors: clinical characteristics and impact of current management on survival.Journal of neuro-oncology · 2020Article
- Late recurrence of choroid plexus carcinoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- DNA methylation signature is prognostic of choroid plexus tumor aggressiveness.Clinical epigenetics · 2019Article
- Perinatal (fetal and neonatal) choroid plexus tumors: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChoroid plexus carcinomas (CPC) are rare brain tumors with a dismal prognosis. Although the role of surgery has been well established, the question of whether chemotherapy improves the prognosis is still under discussion.
methodsWe created a database of all cases of choroid plexus tumors (CPT) reported in the literature up to the year 2004 to determine prognostic factors and different therapeutic modalities. This database was validated by comparison with an existing database of cases until 1997.
resultsOf 857 documented cases of CPT (median patient age at diagnosis, 3 years), 347 were CPC, 15 atypical choroid plexus papilloma (APP), and 495 choroid plexus papilloma (CPP). Histology was a significant prognostic factor (P < .0001; log rank). Within the subgroup of patients with CPC, both surgery and irradiation were linked to a better prognosis (P < .005). The 104 CPC patients who received chemotherapy had a statistically better survival than those without chemotherapy (P = .0004). When subgroups were defined by radiation treatment, chemotherapy remained beneficial in the subgroup of nonirradiated tumors (P = .0001). The benefit of chemotherapy was also significant when the analysis was restricted to the subgroup of patients with less than completely resected CPC (2-year overall survival (OS) 54.8 +/- 7% (standard deviation (SD) vs. 24.4 +/- 7%, P < .0001) and when this subgroup was further divided into smaller subgroups. Likewise, in a multivariate analysis, chemotherapy was highly significantly linked to better prognosis (P = .0001).
conclusionPatients with less than completely resected CPC should receive chemotherapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.