ArticleFolia microbiologica2007
Interleukin- 1 gene polymorphisms as assessed in a 10-year study of patients with early-onset periodontitis.
Article in Folia microbiologica, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Cytokines and Their Genetic Polymorphisms Related to Periodontal Disease.Journal of clinical medicine · 2020Review
- Periodontal inflammation: Integrating genes and dysbiosis.Periodontology 2000 · 2020Review
- Periodontal Infectogenomics.Inflammation and regeneration · 2018Review
- The effect of IL-4 gene polymorphisms on cytokine production in patients with chronic periodontitis and in healthy controls.Mediators of inflammation · 2014Article
- Genetic polymorphisms in chronic hyperplastic sinusitis with nasal polyposis.The Laryngoscope · 2009Article
- Interleukin polymorphisms in aggressive periodontitis: A literature review.Journal of Indian Society of PeriodontologyReview
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
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Abstract
Our 10-year study of early-onset periodontitis (EOP) patients includes repeated clinical observations, microbiological characteristics and analysis of genetic polymorphism of IL-1A and IL-1B genes. Twenty patients (age 15-26 years) were divided according to the clinical status in the 4th year into a group with mean number of teeth with bleeding on probing (BP) 9.8 and mean number of teeth with periodontal pocket (PP) 2.23, and a group with mean number of teeth with BP 5.37 and no PP. Significantly higher values of mean BP and PP were found among the groups during the study but a strong progression of disease was found only in 3 patients. The risk IL-1A allele-2 and IL-1B allele-2 genotype and bacterial presence were analyzed by DNA hybridization methods. No significant differences of bacteria composition (Treponema denticola, Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans) were found between the groups. A higher prevalence of composite IL-1 genotype was detected in the group of EOP patients with progressive disease. Early finding of the disease followed by conservative therapy could positively influence the disease progression. EOP treated in early stages may, but need not, develop into the aggressive form in the presence of risk genotype IL-1.
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