ArticleAmerican journal of respiratory cell and molecular biology2007
Physical and functional interactions of SNAP-23 with annexin A2.
Article in American journal of respiratory cell and molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- The protein interaction networks of mucolipins and two-pore channels.Biochimica et biophysica acta. Molecular cell research · 2019Pooled it
- Syntaxin 4-enhanced plasma membrane repair is independent of dysferlin in skeletal muscle.American journal of physiology. Cell physiology · 2025Article
- Annexin A2 and Kidney Diseases.Frontiers in cell and developmental biology · 2022Review
- Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples.Signal transduction and targeted therapy · 2020Article
- Review
- Synaptotagmin 5 regulates CaJournal of cell science · 2019Article
- Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome-lysosome fusion.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Annexins as Overlooked Regulators of Membrane Trafficking in Plant Cells.International journal of molecular sciences · 2017Review
- Chaperonin (HSP60) and annexin-2 are candidate biomarkers for non-small cell lung carcinoma.Medicine · 2017Article
- The Membrane Phospholipid Binding Protein Annexin A2 Promotes Phagocytosis and Nonlytic Exocytosis of Cryptococcus neoformans and Impacts Survival in Fungal Infection.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- MicroRNA-206 regulates surfactant secretion by targeting VAMP-2.FEBS letters · 2015Article
- TAT-SNAP-23 treatment inhibits the priming of neutrophil functions contributing to shock and/or sepsis-induced extra-pulmonary acute lung injury.Innate immunity · 2015Article
- The Biology of Annexin A2: From Vascular Fibrinolysis to Innate Immunity.Transactions of the American Clinical and Climatological Association · 2015Review
- Synaptotagmin-7 links fusion-activated Ca²⁺ entry and fusion pore dilation.Journal of cell science · 2014Article
- Dynamic reciprocity: the role of annexin A2 in tissue integrity.Journal of cell communication and signaling · 2014Article
- Annexin A2 mediates secretion of collagen VI, pulmonary elasticity and apoptosis of bronchial epithelial cells.Journal of cell science · 2014Article
- Annexin A2 system in human biology: cell surface and beyond.Seminars in thrombosis and hemostasis · 2013Review
- Annexin A7 and SNAP23 interactions in alveolar type II cells and in vitro: a role for Ca(2+) and PKC.Biochimica et biophysica acta · 2012Article
- Physical and functional interaction between the ID1 and p65 for activation of NF-κB.American journal of physiology. Cell physiology · 2012Article
- The human papillomavirus type 16 E5 oncoprotein translocates calpactin I to the perinuclear region.Journal of virology · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Lung surfactant is secreted through the fusion of lamellar bodies with the plasma membrane of alveolar epithelial type II cells. Annexin A2, a Ca(2+)- and phospholipid-binding protein, promotes the fusion of lamellar bodies with the plasma membrane. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are known to have an essential role in surfactant secretion. We hypothesized that annexin A2 acts as a Ca(2+) sensor and mediates membrane fusion via its interaction with SNAREs. Both purified or endogenous annexin A2 in type II cells specifically bound with SNAP-23 in a Ca(2+)-dependent manner, as determined by pull-down experiments using recombinant glutathione S-transferase-tagged SNAP-23. A deletion study identified the cysteine-rich region (CRR) of SNAP-23 as the binding site for annexin A2. Mutations of cysteine residues in the CRR dramatically decreased the binding. SNAP-23 also co-immunoprecipitated with annexin A2; however, a SNAP-23 mutant failed to co-immunoprecipitate with annexin A2. Immunofluorescence revealed a co-localization of SNAP-23 and annexin A2 in type II cells. Furthermore, anti-SNAP-23 antibody significantly inhibited annexin A2-mediated fusion between lamellar bodies and the plasma membrane. These data suggest that annexin A2 and SNAP-23 are involved in the same pathway in the regulation of lung surfactant secretion.
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