Evidence map›Paper›PMID 17575050›Full record

ArticleGenes & development2007

Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms.

Kristoffer Palma, Qingguo Zhao, Yu Ti Cheng, Dongling Bi, Jacqueline Monaghan, Wei Cheng, Yuelin Zhang, Xin Li

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 162 citations in OpenAlex.

  1. Article
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  19. Regulatory Networks of Flowering Genes inPlants (Basel, Switzerland) · 2022
    Article
  20. Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kristoffer PalmaMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Qingguo Zhao
Yu Ti Cheng
Dongling Bi
Jacqueline Monaghan
Wei Cheng
Yuelin Zhang
Xin Li
National Institute of Biological Sciences, Beijing · CNCanada's Michael Smith Genome Sciences Centre · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innate immunity against pathogen infection is an evolutionarily conserved process among multicellular organisms. Arabidopsis SNC1 encodes a Resistance protein that combines attributes of multiple mammalian pattern recognition receptors. Utilizing snc1 as an autoimmune model, we identified a discrete protein complex containing at least three members--MOS4 (Modifier Of snc1, 4), AtCDC5, and PRL1 (Pleiotropic Regulatory Locus 1)--that are all essential for plant innate immunity. AtCDC5 has DNA-binding activity, suggesting that this complex probably regulates defense responses through transcriptional control. Since the complex components along with their interactions are highly conserved from fission yeast to Arabidopsis and human, they may also have a yet-to-be-identified function in mammalian innate immunity.

Indexed as

AnimalsArabidopsisArabidopsis ProteinsCarrier ProteinsGenes, PlantHumansImmunity, InnateMutationNuclear ProteinsPlant ProteinsPlantsRecombinant ProteinsRNA SplicingTwo-Hybrid System TechniquesArabidopsis ProteinsCarrier ProteinsNuclear ProteinsPlant ProteinsPRL1 protein, ArabidopsisRecombinant ProteinsSNC1 protein, Arabidopsis

Identifiers

PMID17575050
PMCPMC1891426
OpenAlexW2103473048

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.