ReviewJournal of substance abuse treatment2008
Substance abuse and schizophrenia: pharmacotherapeutic intervention.
Review in Journal of substance abuse treatment, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- Effects of clozapine treatment on the improvement of substance use disorders other than nicotine in individuals with schizophrenia spectrum disorders: A systematic review and meta-analysis.Journal of psychopharmacology (Oxford, England) · 2023Pooled it
- Place of the partial dopamine receptor agonist aripiprazole in the management of schizophrenia in adults: a Delphi consensus study.BMC psychiatry · 2022Pooled it
- Neuromodulation to Treat Substance Use Disorders in People With Schizophrenia and Other Psychoses: A Systematic Review.Frontiers in psychiatry · 2022Pooled it
- The Impact of THC and CBD in Schizophrenia: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Modafinil augments brain activation associated with reward anticipation in the nucleus accumbens.Psychopharmacology · 2014Trial
- Disparity in immigrant compulsory care assignment: discrimination or response to treatment need.General psychiatry · 2025Article
- Effects of Anticholinergic Burden on Verbal Memory Performance in First-Episode Psychosis.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Article
- Co-medication with disulfiram markedly increased serum clozapine levels: Two case reports.Journal of psychopharmacology (Oxford, England) · 2023Article
- Alcohol drinking in male patients with chronic schizophrenia: prevalence and its relationship to clinical symptoms.Frontiers in psychiatry · 2023Article
- Opioid Use Disorder Among Clients of Community Mental Health Clinics: Prevalence, Characteristics, and Treatment Willingness.Psychiatric services (Washington, D.C.) · 2022Article
- Psychotic symptoms and its association with substance use disorders among adult prisoners in correctional institution: a facility based cross-sectional study in Southwest Ethiopia.African health sciences · 2022Article
- Noninvasive Brain Stimulation for Nicotine Dependence in Schizophrenia: A Mini Review.Frontiers in psychiatry · 2022Review
- The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat.Frontiers in behavioral neuroscience · 2021Article
- Fifty Years of Research on Schizophrenia: The Ascendance of the Glutamatergic Synapse.The American journal of psychiatry · 2020Review
- Understanding marijuana's effects on functional connectivity of the default mode network in patients with schizophrenia and co-occurring cannabis use disorder: A pilot investigation.Schizophrenia research · 2018Article
- Unique Effects of Clozapine: A Pharmacological Perspective.Advances in pharmacology (San Diego, Calif.) · 2018Review
- Effects of iloperidone, combined with desipramine, on alcohol drinking in the Syrian golden hamster.Neuropharmacology · 2016Article
- Professionals' perception on the management of patients with dual disorders.Patient preference and adherence · 2016Article
- Desipramine enhances the ability of paliperidone to decrease alcohol drinking.Journal of psychiatric research · 2015Article
- Clozapine reconstructed: Haloperidol's ability to reduce alcohol intake in the Syrian golden hamster can be enhanced through noradrenergic modulation by desipramine and idazoxan.Drug and alcohol dependence · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Substance use disorder is common in patients with schizophrenia and dramatically worsens their outcome. The typical antipsychotic medications, introduced more than 50 years ago, are effective for the treatment of psychosis but may have only limited efficacy in patients with these co-occurring disorders because patients continue to use substances while taking them. In preliminary studies, however, several of the atypical antipsychotic medications have shown promise for reducing alcohol and drug use in patients with schizophrenia. A neurobiological formulation is discussed, suggesting that the use of substances in patients with schizophrenia may be based on a dysfunction within the dopamine-mediated brain reward circuitry and that clozapine, in particular, may potentially ameliorate this dysfunction and lessen the desire for substance use. Medications for the treatment of alcohol use disorders, such as disulfiram, naltrexone, and acamprosate, as well as other adjunctive medications, may also be useful. Further studies are required to establish a solid evidence base of best practices for the use of medications in these patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.