ArticleThe Journal of cell biology1991
Neural cell adhesion molecule mediates contact-dependent inhibition of growth of near-diploid mouse fibroblast cell line m5S/1M.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
- The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth.Carcinogenesis · 2010Review
- A 3D hybrid model for tissue growth: the interplay between cell population and mass transport dynamics.Biophysical journal · 2009Article
- Akt phosphorylation of merlin enhances its binding to phosphatidylinositols and inhibits the tumor-suppressive activities of merlin.Cancer research · 2009Article
- Cell population dynamics modulate the rates of tissue growth processes.Biophysical journal · 2006Article
- Expression of cell adhesion molecules in oesophageal carcinoma and its prognostic value.Journal of clinical pathology · 2005Review
- The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44.Genes & development · 2001Article
- E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1).The Journal of cell biology · 1998Article
- Neural cell adhesion molecule (N-CAM) domains and intracellular signaling pathways involved in the inhibition of astrocyte proliferation.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family.The Journal of cell biology · 1997Article
- Glucocorticoid receptor pathways are involved in the inhibition of astrocyte proliferation.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Epidermal growth factor modulates cell attachment to hyaluronic acid by the cell surface glycoprotein CD44.Clinical & experimental metastasis · 1996Article
- The neural cell adhesion molecule (N-CAM) inhibits proliferation in primary cultures of rat astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Regulation of Mel-CAM/MUC18 expression on melanocytes of different stages of tumor progression by normal keratinocytes.The American journal of pathology · 1994Article
- Thy-1 triggers mouse thymocyte apoptosis through a bcl-2-resistant mechanism.The Journal of experimental medicine · 1994Article
- Increasing N-CAM-mediated cell-cell adhesion does not reduce invasion of RSV-transformed WC5 rat cerebellar cells.Clinical & experimental metastasis · 1993Article
- Adhesion molecules and their role in cancer metastasis.Cell biophysicsReview
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A near-diploid mouse fibroblast cell line m5S/1M used in this study shows a high sensitivity to contact-dependent inhibition of growth, and the addition of EGF causes both morphological change and loss of contact-dependent inhibition of growth. The m5S/1M cell and its transformants obtained by x-ray irradiation have been used to search for the cell surface glycoproteins that are responsible for the growth regulation via cell-cell interactions. Lectin blotting analyses showed that the expression of the cell surface glycoprotein of 140 kD (140KGP) is highly sensitive to the transformation induced either by x-ray irradiation or by the EGF stimulation. We purified the 140KGP and found that it was composed of two glycoproteins. The major component of 140KGP was identified as neural cell adhesion molecule (NCAM) by amino acid sequence analyses of the peptide fragments and by the cross-reactivity with anti-NCAM mAb, clone H28.1.2.3. Monoclonal antibody against 140KGP (clone LN-10) recognizes all three isoforms of NCAM expressed on m5S/1M cell and showed that the expression of NCAM was highly sensitive to the transformation. Furthermore, the immobilized LN-10 strongly inhibited the growth of actively proliferating m5S/1M cells and the LN-10 in a soluble form showed a significant growth-stimulating effect on the confluent quiescent cultures of m5S/1M cells. The results show that NCAM plays a major role in the contact-dependent inhibition of growth of m5S/1M, and that NCAM might be involved in the regulation of cell growth during embryogenesis and formation of nervous systems.
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