ArticleMycopathologia2007
A genome-wide steroid response study of the major human fungal pathogen Candida albicans.
Article in Mycopathologia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Capsaicin inhibits cariogenicJournal of oral microbiology · 2026Article
- Overexpression of the White Opaque Switching Master Regulator Wor1 Alters Lipid Metabolism and Mitochondrial Function inJournal of fungi (Basel, Switzerland) · 2022Article
- The Flavonoid Baicalein Negatively Regulates Progesterone Target Genes in the UterusJournal of natural products · 2022Article
- Deletion of the Stress Response GeneJournal of fungi (Basel, Switzerland) · 2021Article
- Adrenal Steroids Modulate Fibroblast-Like Synoviocytes Response DuringFrontiers in endocrinology · 2019Article
- Estimation of Candida albicans ABC Transporter Behavior in Real-Time via Fluorescence.Frontiers in microbiology · 2015Article
- Communication between Bacteria and Their Hosts.Scientifica · 2013Review
- Fluconazole transport into Candida albicans secretory vesicles by the membrane proteins Cdr1p, Cdr2p, and Mdr1p.Eukaryotic cell · 2010Article
- Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance.Antimicrobial agents and chemotherapy · 2009Article
- Responses of pathogenic and nonpathogenic yeast species to steroids reveal the functioning and evolution of multidrug resistance transcriptional networks.Eukaryotic cell · 2008Article
- Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the absence of steroid receptors and any known mechanism of gene regulation by steroid hormones in Candida albicans, we did a genome-wide analysis of C. albicans cells treated with progesterone using Eurogentec cDNA microarrays to find the complete repertoire of steroid responsive genes. Northern blotting analysis was employed to validate the genes that were differentially regulated by progesterone in the microarray experiments. A total of 99 genes were found to be significantly regulated by progesterone, among them 60 were up-regulated and 39 were down-regulated. It was observed that progesterone considerably enhanced the expression of multi-drug resistance (MDR) genes belonging to ATP Binding Cassette (CDR1 and CDR2) super-family of multidrug transporters, suggesting a possible relationship between steroid stress and MDR genes. Several genes associated with hyphal induction and the establishment of pathogenesis were also found up-regulated. In silico search for various transcription factor (TF) binding sites in the promoter of the affected genes revealed that EFG1, CPH1, NRG1, TUP1, MIG1 and AP-1 regulated genes are responsive to progesterone. The stress responsive elements (STRE; AG(4) or C(4)T) were also found in the promoters of several responsive genes. Our data sheds new light on the regulation of gene expression in C. albicans by human steroids, and its correlation with drug resistance, virulence, morphogenesis and general stress response. A comparison with drug induced stress response has also been discussed.
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Registered trials
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