ArticleJournal of cancer research and clinical oncology2007
The influence of different microenvironments on melanoma invasiveness and microcirculation patterns: an animal experiment study in the mouse model.
Article in Journal of cancer research and clinical oncology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Epithelial-to-endothelial transition and cancer stem cells: two cornerstones of vasculogenic mimicry in malignant tumors.Oncotarget · 2017Review
- Nodal signaling promotes vasculogenic mimicry formation in breast cancer via the Smad2/3 pathway.Oncotarget · 2016Article
- Twist1 expression induced by sunitinib accelerates tumor cell vasculogenic mimicry by increasing the population of CD133+ cells in triple-negative breast cancer.Molecular cancer · 2014Article
- Blood biomarkers for uveal melanoma.Future oncology (London, England) · 2012Review
- Article
- Proliferation of human lung cancer in an orthotopic transplantation mouse model.Experimental and therapeutic medicine · 2010Article
- A pilot study on acute inflammation and cancer: a new balance between IFN-gamma and TGF-beta in melanoma.Journal of experimental & clinical cancer research : CR · 2009Article
- Current concepts of metastasis in melanoma.Expert review of dermatology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectTo investigate the influence of different microenvironments on tumor microcirculation patterns and invasiveness capability.
methodsMelanoma B16 cells were injected into the abdominal cavity and skeletal muscle of C57 mice synchronously. CK-18 expression in melanoma was assessed to distinguish the malignant phenotype of tumors in the abdominal cavity from that in the skeletal muscle. HIF-1alpha, MMP-2 and MMP-9 expression and mRNA levels of MMP-2 and MMP-9 was detected to compare the mRNA levels of MMP-2 and MMP-9 from the two microenvironments. Cells positive for each immunohistochemical stain and the vessels representative of each type of microcirculation pattern were counted in two microenvironments.
resultsCK-18 and HIF-1alpha expression of melanoma were significantly higher in the skeletal muscle than in the abdominal cavity (P<0.05). Compared with the abdominal cavity, melanoma cells in the skeletal muscle overexpressed MMP-2 and MMP-9 (P<0.05). Real time-PCR results also showed that MMP-2 and MMP-9 mRNA levels of melanoma were higher in the skeletal muscle than in the abdominal cavity (P<0.05). VM channels and endothelium-dependent vessels were the major microcirculation pattern in the skeletal muscle and in the abdominal cavity, respectively.
conclusionDifferent microenvironments affect invasiveness and blood supply patterns of melanoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.