ArticleGenome biology2007
LongSAGE analysis of skeletal muscle at three prenatal stages in Tongcheng and Landrace pigs.
Article in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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71 citing papers in PubMed, 136 citations in OpenAlex.
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- Integration of multi-omics data reveals cis-regulatory variants that are associated with phenotypic differentiation of eastern from western pigs.Genetics, selection, evolution : GSE · 2022Article
- Notch signaling leads to a slower progression of embryonic myogenic differentiation in Landrace than in Langtang pigs.Acta biochimica et biophysica Sinica · 2022Article
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- circRNAome profiling reveals circFgfr2 regulates myogenesis and muscle regeneration via a feedback loop.Journal of cachexia, sarcopenia and muscle · 2022Article
- Gut Bacterial Composition and Functional Potential of Tibetan Pigs Under Semi-Grazing.Frontiers in microbiology · 2022Article
- The genome variation and developmental transcriptome maps reveal genetic differentiation of skeletal muscle in pigs.PLoS genetics · 2021Article
- A compendium and comparative epigenomics analysis of cis-regulatory elements in the pig genome.Nature communications · 2021Article
- Transcriptome Analysis of mRNAs and Long Non-Coding RNAs During Subsequent Embryo Development of Porcine Cloned Zygotes After Vitrification.Frontiers in genetics · 2021Article
- Proteomic Exploration of Porcine Oocytes During Meiotic MaturationFrontiers in veterinary science · 2021Article
- Validation of the Reference Genes for the Gene Expression Studies in Different Cell Lines of Pig.BioMed research international · 2021Article
- Analysis of Transcriptome and miRNAome in the Muscle of Bamei Pigs at Different Developmental Stages.Animals : an open access journal from MDPI · 2020Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObese and lean pig breeds show obvious differences in muscle growth; however, the molecular mechanism underlying phenotype variation remains unknown. Prenatal muscle development programs postnatal performance. Here, we describe a genome-wide analysis of differences in prenatal skeletal muscle between Tongcheng (a typical indigenous Chinese breed) and Landrace (a leaner Western breed) pigs.
resultsWe generated transcriptome profiles of skeletal muscle from Tongcheng and Landrace pigs at 33, 65 and 90 days post coitus (dpc), using long serial analysis of gene expression (LongSAGE). We sequenced 317,115 LongSAGE tags and identified 1,400 and 1,201 differentially expressed transcripts during myogenesis in Tongcheng and Landrace pigs, respectively. From these, the Gene Ontology processes and expression patterns of these differentially expressed genes were constructed. Most of the genes showed different expression patterns in the two breeds. We also identified 532, 653 and 459 transcripts at 33, 65 and 90 dpc, respectively, that were differentially expressed between the two breeds. Growth factors, anti-apoptotic factors and genes involved in the regulation of protein synthesis were up-regulated in Landrace pigs. Finally, 12 differentially expressed genes were validated by quantitative PCR.
conclusionOur data show that gene expression phenotypes differ significantly between the two breeds. In particular, a slower muscle growth rate and more complicated molecular changes were found in Tongcheng pigs, while genes responsible for increased cellular growth and myoblast survival were up-regulated in Landrace pigs. Our analyses will assist in the identification of candidate genes for meat production traits and elucidation of the development of prenatal skeletal muscle in mammals.
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