SynthesisCritical care (London, England)2007
Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis.
Synthesis in Critical care (London, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Exogenous surfactant may improve oxygenation but not mortality in adult patients with acute lung injury/acute respiratory distress syndrome: a meta-analysis of 9 clinical trials.Journal of cardiothoracic and vascular anesthesia · 2012Pooled it
- The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.PLoS medicine · 2009Guideline
- The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration.BMJ (Clinical research ed.) · 2009Guideline
- Pediatric acute respiratory distress syndrome in children with type I - spinal muscular atrophy: a 12-year case series.European journal of pediatrics · 2025Article
- Mechanical Ventilation during ECMO: Best Practices.Respiratory care · 2023Review
- Prevalence, Predictive Factors, and Outcomes of Respiratory Failure in Children With Pneumonia Admitted in a Developing Country.Frontiers in pediatrics · 2022Article
- The Use of Exogenous Lung Surfactant (Poractant Alfa) in Acute Respiratory Failure by Drowning.Case reports in critical care · 2020Article
- Extended use of the modified Berlin Definition based on age-related subgroup analysis in pediatric ARDS.Wiener medizinische Wochenschrift (1946) · 2019Article
- Pediatric Acute Respiratory Distress Syndrome: Fibrosis versus Repair.Frontiers in pediatrics · 2016Review
- Role of Inhaled Nitric Oxide in the Management of Severe Acute Respiratory Distress Syndrome.Frontiers in pediatrics · 2016Review
- Exogenous pulmonary surfactant for acute respiratory distress syndrome in adults: A systematic review and meta-analysis.Experimental and therapeutic medicine · 2013Article
- Management of acute lung injury/ARDS.Indian journal of pediatrics · 2010Article
- Overcoming rapid inactivation of lung surfactant: analogies between competitive adsorption and colloid stability.Biochimica et biophysica acta · 2010Review
- Surfactant-associated protein B is critical to survival in nickel-induced injury in mice.American journal of respiratory cell and molecular biology · 2009Article
- Competitive adsorption: a physical model for lung surfactant inactivation.Langmuir : the ACS journal of surfaces and colloids · 2009Article
- Mechanisms of polyelectrolyte enhanced surfactant adsorption at the air-water interface.Biochimica et biophysica acta · 2009Article
- Surfactant for acute respiratory failure in children: where should it fit in our treatment algorithm?Critical care (London, England) · 2007Article
Corrections and comments
- Commented on by
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionExogenous surfactant is used to treat acute respiratory failure in children, although the benefits and harms in this setting are not clear. The objective of the present systematic review is to assess the effect of exogenous pulmonary surfactant on all-cause mortality in children mechanically ventilated for acute respiratory failure.
methodsWe searched the MEDLINE, EMBASE, CINAHL and Ovid Healthstar databases, the bibliographies of included trials and review articles, conference proceedings and trial registries. We included prospective, randomized, controlled trials of pulmonary surfactant that enrolled intubated and mechanically ventilated children with acute respiratory failure. We excluded trials that exclusively enrolled neonates or patients with asthma. Two reviewers independently rated trials for inclusion, extracted data and assessed the methodologic quality. We quantitatively pooled the results of trials, where suitable, using a random effects model.
resultsSix trials randomizing 314 patients were included. Surfactant use reduced mortality (relative risk = 0.7, 95% confidence interval = 0.4 to 0.97, P = 0.04), was associated with increased ventilator-free days (weighted mean difference = 2.5 days, 95% confidence interval = 0.3 to 4.6 days, P = 0.02) and reduced the duration of ventilation (weighted mean difference = 2.3 days, 95% confidence interval = 0.1 to 4.4 days, P = 0.04).
conclusionSurfactant use decreased mortality, was associated with more ventilator-free days and reduced the duration of ventilation. No serious adverse events were reported.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.