ArticleEukaryotic cell2007
Frataxin, a conserved mitochondrial protein, in the hydrogenosome of Trichomonas vaginalis.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis.PLoS pathogens · 2023Article
- Group-specific functional patterns of mitochondrion-related organelles shed light on their multiple transitions from mitochondria in ciliated protists.Marine life science & technology · 2022Article
- Inheritance of the reduced mitochondria of Giardia intestinalis is coupled to the flagellar maturation cycle.BMC biology · 2021Article
- Fe-S cluster assembly in the supergroup Excavata.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018Review
- Frataxin Is Localized to Both the Chloroplast and Mitochondrion and Is Involved in Chloroplast Fe-S Protein Function in Arabidopsis.PloS one · 2015Article
- Analysis of the Sam50 translocase of excavate organisms supports evolution of divergent organelles from a common endosymbiotic event.Bioscience reports · 2013Article
- Hydrogenosomes in the diplomonad Spironucleus salmonicida.Nature communications · 2013Article
- Biochemistry and evolution of anaerobic energy metabolism in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2012Review
- Article
- Transcriptomic identification of iron-regulated and iron-independent gene copies within the heavily duplicated Trichomonas vaginalis genome.Genome biology and evolution · 2012Article
- The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria, yet complex compared with mitosomes.International journal for parasitology · 2011Article
- Sawyeria marylandensis (Heterolobosea) has a hydrogenosome with novel metabolic properties.Eukaryotic cell · 2010Article
- Friedreich ataxia: molecular mechanisms, redox considerations, and therapeutic opportunities.Antioxidants & redox signaling · 2010Review
- Frataxin and mitochondrial FeS cluster biogenesis.The Journal of biological chemistry · 2010Review
- Diversity and reductive evolution of mitochondria among microbial eukaryotes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Mitochondrion-related organelles in eukaryotic protists.Annual review of microbiology · 2010Review
- The monothiol single-domain glutaredoxin is conserved in the highly reduced mitochondria of Giardia intestinalis.Eukaryotic cell · 2009Article
- The pathogenesis of Friedreich ataxia and the structure and function of frataxin.Journal of neurology · 2009Review
- Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
Recent data suggest that frataxin plays a key role in eukaryote cellular iron metabolism, particularly in mitochondrial heme and iron-sulfur (FeS) cluster biosynthesis. We have now identified a frataxin homologue (T. vaginalis frataxin) from the human parasite Trichomonas vaginalis. Instead of mitochondria, this unicellular eukaryote possesses hydrogenosomes, peculiar organelles that produce hydrogen but nevertheless share common ancestry with mitochondria. T. vaginalis frataxin contains conserved residues implicated in iron binding, and in silico, it is predicted to form a typical alpha-beta sandwich motif. The short N-terminal extension of T. vaginalis frataxin resembles presequences that target proteins to hydrogenosomes, a prediction confirmed by the results of overexpression of T. vaginalis frataxin in T. vaginalis. When expressed in the mitochondria of a frataxin-deficient Saccharomyces cerevisiae strain, T. vaginalis frataxin partially restored defects in heme and FeS cluster biosynthesis. Although components of heme synthesis or heme-containing proteins have not been found in T. vaginalis to date, T. vaginalis frataxin was also shown to interact with S. cerevisiae ferrochelatase by using a Biacore assay. The discovery of conserved iron-metabolizing pathways in mitochondria and hydrogenosomes provides additional evidence not only of their common evolutionary history, but also of the fundamental importance of this pathway for eukaryotes.
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