ArticleJournal of bacteriology2007
Comparative analysis of the regulation of rovA from the pathogenic yersiniae.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The Yersinia pseudotuberculosis Cpx envelope stress system contributes to transcriptional activation of rovM.Virulence · 2019Article
- Article
- Control of virulence gene transcription by indirect readout in Vibrio cholerae and Salmonella enterica serovar Typhimurium.Environmental microbiology · 2017Review
- Vibrio cholerae leuO Transcription Is Positively Regulated by ToxR and Contributes to Bile Resistance.Journal of bacteriology · 2015Article
- Transcriptomic profiling of Yersinia pseudotuberculosis reveals reprogramming of the Crp regulon by temperature and uncovers Crp as a master regulator of small RNAs.PLoS genetics · 2015Article
- Article
- The Salmonella enterica serovar Typhi LeuO global regulator forms tetramers: residues involved in oligomerization, DNA binding, and transcriptional regulation.Journal of bacteriology · 2014Article
- IscR is essential for yersinia pseudotuberculosis type III secretion and virulence.PLoS pathogens · 2014Article
- The Subtleties and Contrasts of the LeuO Regulator in Salmonella Typhi: Implications in the Immune Response.Frontiers in immunology · 2014Review
- Human and animal isolates of Yersinia enterocolitica show significant serotype-specific colonization and host-specific immune defense properties.Infection and immunity · 2013Article
- Molecular basis of Yersinia enterocolitica temperature-dependent resistance to antimicrobial peptides.Journal of bacteriology · 2012Article
- Transcriptional regulation of the assT-dsbL-dsbI gene cluster in Salmonella enterica serovar Typhi IMSS-1 depends on LeuO, H-NS, and specific growth conditions.Journal of bacteriology · 2012Article
- OmpR, a response regulator of the two-component signal transduction pathway, influences inv gene expression in Yersinia enterocolitica O9.Frontiers in cellular and infection microbiology · 2012Article
- Unique cell adhesion and invasion properties of Yersinia enterocolitica O:3, the most frequent cause of human Yersiniosis.PLoS pathogens · 2011Article
- Molecular characterization of transcriptional regulation of rovA by PhoP and RovA in Yersinia pestis.PloS one · 2011Article
- Phosphorylated CpxR restricts production of the RovA global regulator in Yersinia pseudotuberculosis.PloS one · 2011Article
- BglJ-RcsB heterodimers relieve repression of the Escherichia coli bgl operon by H-NS.Journal of bacteriology · 2010Article
- SlyA, a MarR family transcriptional regulator, is essential for virulence in Dickeya dadantii 3937.Journal of bacteriology · 2009Article
- Intrinsic thermal sensing controls proteolysis of Yersinia virulence regulator RovA.PLoS pathogens · 2009Article
- The LysR-type transcriptional regulator LeuO controls expression of several genes in Salmonella enterica serovar Typhi.Journal of bacteriology · 2008Article
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2 authors.
Funding
Abstract
RovA is a MarR/SlyA-type regulator that mediates the transcription of inv in Yersinia enterocolitica and Y. pseudotuberculosis. In Y. pseudotuberculosis, rovA transcription is controlled primarily by H-NS and RovA, which bind to similar regions within the rovA promoter. At 37 degrees C, rovA transcription is repressed by H-NS. Transcription of rovA results when RovA relieves H-NS-mediated repression. The region of the rovA promoter that H-NS and RovA bind is not conserved in the Y. enterocolitica promoter. Using green fluorescent protein reporters, we determined that the Y. enterocolitica rovA (rovA(Yent)) promoter is weaker than the Y. pseudotuberculosis promoter. However, despite the missing H-NS/RovA binding site in the rovA(Yent) promoter, H-NS and RovA are still involved in the regulation of rovA(Yent). DNA binding studies suggest that H-NS and RovA bind with a higher affinity to the Y. pseudotuberculosis/Y. pestis rovA (rovA(Ypstb/Ypestis)) promoter than to the rovA(Yent) promoter. Furthermore, H-NS appears to bind to two regions in a cooperative fashion within the rovA(Yent) promoter that is not observed with the rovA(Ypstb/Ypestis) promoter. Finally, using a transposon mutagenesis approach, we identified a new positive regulator of rovA in Y. enterocolitica, LeuO. In Escherichia coli, LeuO regulates gene expression via changes in levels of RpoS and H-NS, but LeuO-mediated regulation of rovA(Yent) appears to be independent of either of these two proteins. Together, these data demonstrate that while the rovA regulatory factors are conserved in Yersinia, divergence of Y. enterocolitica and Y. pseudotuberculosis/Y. pestis during evolution has resulted in modifications in the mechanisms that are responsible for controlling rovA transcription.
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