ArticleBiophysical journal2007
The electrophysiology of the beta-cell based on single transmembrane protein characteristics.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- β Cells Operate Collectively to Help Maintain Glucose Homeostasis.Biophysical journal · 2020Article
- Insulin Release Mechanism Modulated by Toxins Isolated from Animal Venoms: From Basic Research to Drug Development Prospects.Molecules (Basel, Switzerland) · 2019Review
- Closing in on the Mechanisms of Pulsatile Insulin Secretion.Diabetes · 2018Article
- Modeling K,ATP--dependent excitability in pancreatic islets.Biophysical journal · 2014Article
- Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics.Trends in endocrinology and metabolism: TEM · 2014Review
- Mathematical models of electrical activity of the pancreatic β-cell: a physiological review.Islets · 2014Review
- A mathematical model of T lymphocyte calcium dynamics derived from single transmembrane protein properties.Frontiers in immunology · 2013Article
- Ionic mechanisms and Ca2+ dynamics underlying the glucose response of pancreatic β cells: a simulation study.The Journal of general physiology · 2011Article
- A biophysical model of electrical activity in human β-cells.Biophysical journal · 2010Article
- Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms.American journal of physiology. Endocrinology and metabolism · 2010Review
- Lessons from models of pancreatic beta cells for engineering glucose-sensing cells.Mathematical biosciences · 2010Review
- A mathematical model of β-cells in an islet of Langerhans sensing a glucose gradient.HFSP journal · 2010Article
- Pancreatic islet cells: a model for calcium-dependent peptide release.HFSP journal · 2010Article
- Modeling of the gap junction of pancreatic β-cells and the robustness of insulin secretion.Biophysics (Nagoya-shi, Japan) · 2010Article
- Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion.Endocrinology · 2009Article
- Contributions of mathematical modeling of beta cells to the understanding of beta-cell oscillations and insulin secretion.Journal of diabetes science and technology · 2009Review
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1 author.
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Abstract
The electrophysiology of beta-cells is at the origin of insulin secretion. beta-Cells exhibit a complex behavior upon stimulation with glucose including repeated bursts and continuous spiking. Mathematical modeling is most suitable to improve knowledge about the function of various transmembrane currents provided the model is based on reliable data. This is the first attempt to build a mathematical model for the beta-cell electrophysiology in a bottom-up approach that relies on single protein conductance data. The results of previous whole-cell-based models are reconsidered. The full simulation including all prominent transmembrane proteins in beta-cells is used to provide a functional interpretation of their role in beta-cell bursting and an updated vantage point of beta-cell electrophysiology. As a result of a number of in silico knock-out and block experiments the novel model makes some unexpected predictions: single-channel conductance data imply that large-conductance calcium-gated potassium currents acquire the potential of driving oscillations at supralarge glucose levels. A more complex burst interruption model is presented. It also turns out that, depending on the species, sodium currents may be more relevant than considered so far. Experiments are proposed to verify these predictions.
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