ArticleIntensive care medicine2007
Renal blood flow and function during recovery from experimental septic acute kidney injury.
Article in Intensive care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- The histopathology of septic acute kidney injury: a systematic review.Critical care (London, England) · 2008Pooled it
- Heterogeneity in the response to a high vs low mean arterial pressure target in patients with septic shock a post hoc analysis of a randomized controlled trial.Intensive care medicine · 2025Trial
- Trial
- Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram-negative septic acute kidney injury.Experimental physiology · 2025Article
- Professor Rinaldo Bellomo: Founder, architect, and choreographer of critical care nephrology.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Review
- Impaired angiotensin II signaling in septic shock.Annals of intensive care · 2024Review
- Crosstalk between COVID-19 Infection and Kidney Diseases: A Review on the Metabolomic Approaches.Vaccines · 2023Review
- The Interplay of Oxidative Stress and ROS Scavenging: Antioxidants as a Therapeutic Potential in Sepsis.Vaccines · 2022Review
- The role of nitric oxide in sepsis-associated kidney injury.Bioscience reports · 2022Article
- Incidence, risk factors and clinical outcomes of septic acute renal injury in cancer patients with sepsis admitted to the ICU: A retrospective study.Frontiers in medicine · 2022Article
- Sepsis-induced AKI: From pathogenesis to therapeutic approaches.Frontiers in pharmacology · 2022Review
- Pathophysiology of COVID-19-associated acute kidney injury.Nature reviews. Nephrology · 2021Review
- Kidney Microcirculation as a Target for Innovative Therapies in AKI.Journal of clinical medicine · 2021Review
- Renal echography for predicting acute kidney injury in critically ill patients: a prospective observational study.Renal failure · 2020Observational
- Lessons learned from kidney dysfunction : Preventing organ failure.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Review
- Mitochondrial Metabolism in Acute Kidney Injury.Seminars in nephrology · 2020Review
- Article
- Recent advances in the pathogenetic mechanisms of sepsis-associated acute kidney injury.Journal of nephrology · 2018Review
- The role of adenosine 1a receptor signaling on GFR early after the induction of sepsis.American journal of physiology. Renal physiology · 2018Article
- Urine biochemistry assessment in critically ill patients: controversies and future perspectives.Journal of clinical monitoring and computing · 2017Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo measure renal blood flow (RBF) and renal function during recovery from experimental septic acute kidney injury (AKI).
designControlled experimental study. SUBJECTS: Nine merino ewes.
settingUniversity physiology laboratory.
interventionWe recorded systemic and renal hemodynamics during a 96-h observation period (control) via implanted transit-time flow probes. We then compared this period with 96[Symbol: see text]h of septic AKI (48 h of Escherichia coli infusion) and subsequent recovery (48 h of observation after stopping E. coli). MEASUREMENTS AND
resultsCompared with the control period, E. coli infusion induced hyperdynamic sepsis (increased cardiac output and decreased blood pressure) and septic AKI (serum creatinine 65.4 +/- 8.7 vs. 139.9 +/- 33.0 micromol/l; creatinine clearance 73.8 +/- 12.2 vs. 40.2 +/- 17.2 ml/min; p < 0.05) with a mortality of 22%. RBF increased (278.8 +/- 33.9 vs. 547.9 +/- 124.8 ml/min; p < 0.05) as did renal vascular conductance (RVC). During recovery, we observed a decrease in RVC and RBF with all values returning to control levels. Indices of tubular function [fractional excretion of sodium (FENa) and urea (FEUn) and urinary sodium concentration (UNa)], which had been affected by sepsis, returned to control values after 18 h of recovery, as did serum creatinine.
conclusionsInfusion of E. coli induced a hyperdynamic circulatory state with hyperemic AKI. Recovery was associated with relative renal vasoconstriction and reduction in RBF and RVC back to control levels. Indices of tubular function normalized more rapidly than changes in RBF.
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