Evidence map›Paper›PMID 17572843›Full record

ArticleMedical molecular morphology2007

Vascular endothelial growth factor expression in rat skin incision wound.

Makoto Nogami, Tomoaki Hoshi, Mayumi Kinoshita, Tomomi Arai, Michiho Takama, Ichiro Takahashi

Abstract read
PubMed Publisher
In one paragraph

Article in Medical molecular morphology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
  5. Article
  6. Article
  7. Traditional Japanese formula kigikenchuto accelerates healing of pressure-loading skin ulcer in rats.Evidence-based complementary and alternative medicine : eCAM · 2011
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Makoto NogamiDepartment of Legal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan. mnogami@med.teikyo-u.ac.jp
Tomoaki Hoshi
Mayumi Kinoshita
Tomomi Arai
Michiho Takama
Ichiro Takahashi
Teikyo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular endothelial growth factor (VEGF) is a glycoprotein that enhances vascular permeability, induces chemotaxis and activation of monocytes/macrophages, and promotes growth of vascular endothelial cells. We report that infiltrating polymorphonuclear leukocytes in an incision wound in rat skin express VEGF from 1 day after the injury, as shown by immunohistochemistry. VEGF is also present in macrophages, fibroblast-like cells, and endothelial cells 3 and 7 days after the injury. mRNA for VEGF is statistically significantly increased in the wound area in the tissue 1 day after the skin incision compared with 3 and 7 days after the incision. The VEGF protein content in the wound tissue is statistically significantly higher in the wound than in control skin at 1 and 3 days after skin incision. Our results indicate that VEGF is produced by inflammatory cells to induce vascularization in the early stage of the wound healing process.

Indexed as

Analysis of VarianceAnimalsGene Expression RegulationImmunohistochemistryMaleNeovascularization, PhysiologicPlatelet Endothelial Cell Adhesion Molecule-1RatsRats, Sprague-DawleyReceptors, Vascular Endothelial Growth FactorRNA, MessengerSkinUp-RegulationVascular Endothelial Growth Factor AWound HealingWounds, PenetratingPlatelet Endothelial Cell Adhesion Molecule-1Receptors, Vascular Endothelial Growth FactorRNA, MessengerVascular Endothelial Growth Factor A

Identifiers

PMID17572843
OpenAlexW1992369502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.