ReviewMedical molecular morphology2007
Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia.
Review in Medical molecular morphology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 102 citations in OpenAlex.
- APC in the nervous system.Medical molecular morphology · 2026Review
- Murine Models of Obesity-Related Cancer Risk.Cancer prevention research (Philadelphia, Pa.) · 2025Review
- Altered microbiota caused by disordered gut motility leads to an overactivation of intestinal immune system in APC1638T mice.Medical molecular morphology · 2023Article
- Decreased Podocyte Vesicle Transcytosis and Albuminuria inInternational journal of molecular sciences · 2021Article
- A further study on a disturbance of intestinal epithelial cell population and kinetics in APC1638T mice.Medical molecular morphology · 2021Article
- Morphological and functional abnormalities of hippocampus in APCMedical molecular morphology · 2021Article
- Immune Microenvironment: New Insight for Familial Adenomatous Polyposis.Frontiers in oncology · 2021Review
- The Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and Therapy.Iranian biomedical journal · 2020Review
- Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting.Cancer metastasis reviews · 2018Review
- Protective and Restorative Effects of Nutrients and Phytochemicals.The open biochemistry journal · 2018Review
- A disturbance of intestinal epithelial cell population and kinetics in APC1638T mice.Medical molecular morphology · 2017Article
- Insights into the role of the intestinal microbiota in colon cancer.Therapeutic advances in gastroenterology · 2017Review
- Beta-catenin Forms Protein Aggregation at High Concentrations in HEK293TCells.Iranian journal of medical sciences · 2017Article
- Regulatory single nucleotide polymorphisms (rSNPs) at the promoters 1A and 1B of the human APC gene.BMC genetics · 2016Article
- Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells.The Journal of nutrition · 2016Article
- APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.Molecular biology of the cell · 2016Article
- Mieap suppresses murine intestinal tumor via its mitochondrial quality control.Scientific reports · 2015Article
- Genetic dissection of the Mom5 modifier locus and evaluation of Mom5 candidate genes.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Altered Interactions between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APCMin/+ Mice.PloS one · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis and in most sporadic colorectal tumors. During both embryonic and postnatal periods, APC is widely expressed in a variety of tissues, including the brain and gastrointestinal tract. The APC gene product (APC) is a large multidomain protein consisting of 2843 amino acids. APC downregulates the Wnt signaling pathway through its binding to beta-catenin and Axin. Most mutated APC proteins in colorectal tumors lack the beta-catenin-binding regions and fail to inhibit Wnt signaling, leading to the overproliferation of tumor cells. Several mouse models (APC580D, APCDelta716, APC1309, APCMin, APC1638T) have been established to investigate carcinogenesis caused by APC mutations. APC also binds to APC-stimulated guanine nucleotide exchange factor, the kinesin superfamily-associated protein 3, IQGAP1, microtubules, EB1, and discs large (DLG). APC has both nuclear localization signals and nuclear export signals in its molecule, suggesting its occasional nuclear localization and export of beta-catenin from the nucleus. APC is highly expressed in the intestinal and colorectal epithelia and may be involved in homeostasis of the enterocyte renewal phenomena, in which proliferation, migration, differentiation, and apoptosis are highly regulated both temporally and spatially. Through the many binding proteins mentioned, APC can exert multiple functions involved in epithelial homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.