ArticleMolecular diagnosis & therapy2007
The pharmacogenetics of lithium response depends upon clinical co-morbidity.
Article in Molecular diagnosis & therapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Impact of Posttraumatic Stress Disorder on Pharmacologic Intervention Outcomes for Adults With Bipolar Disorder: A Systematic Review.The international journal of neuropsychopharmacology · 2023Pooled it
- A systematic review and meta-analysis of clinical predictors of lithium response in bipolar disorder.Acta psychiatrica Scandinavica · 2019Pooled it
- Genetics of serum BDNF: meta-analysis of the Val66Met and genome-wide association study.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2013Pooled it
- Genetic predictors of lithium response in an ethiopian cohort of patients with bipolar disorder.Annals of general psychiatry · 2026Article
- Genetic variants in GRIN2B and NTRK2 on the etiology and treatment response to valproate and lithium in patients with bipolar disorder.Pharmacological reports : PR · 2025Article
- Does Post-traumatic Stress Disorder Impact Treatment Outcomes within a Randomised Controlled Trial of Mitochondrial Agents for Bipolar Depression?Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Genetic and Epigenetic Markers of Lithium Response.International journal of molecular sciences · 2022Review
- An Analysis of FiveDisease markers · 2020Article
- Ancestral Stress Alters Lifetime Mental Health Trajectories and Cortical Neuromorphology via Epigenetic Regulation.Scientific reports · 2019Article
- The Role of Pharmacogenomics in Bipolar Disorder: Moving Towards Precision Medicine.Molecular diagnosis & therapy · 2018Review
- Molecular actions and clinical pharmacogenetics of lithium therapy.Pharmacology, biochemistry, and behavior · 2014Review
- Response to lithium in bipolar disorder: clinical and genetic findings.ACS chemical neuroscience · 2014Review
- Towards the clinical implementation of pharmacogenetics in bipolar disorder.BMC medicine · 2014Article
- Neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene associated with treatment response to mood stabilizers in patients with bipolar I disorder.Journal of molecular neuroscience : MN · 2013Article
- Genetic influences on response to mood stabilizers in bipolar disorder: current status of knowledge.CNS drugs · 2013Review
- The interaction of BDNF and NTRK2 gene increases the susceptibility of paranoid schizophrenia.PloS one · 2013Article
- The role of BDNF, NTRK2 gene and their interaction in development of treatment-resistant depression: data from multicenter, prospective, longitudinal clinic practice.Journal of psychiatric research · 2013Article
- Increased ratio of anti-apoptotic to pro-apoptotic Bcl2 gene-family members in lithium-responders one month after treatment initiation.Biology of mood & anxiety disorders · 2012Article
- Functional genetic variation in the Rev-Erbα pathway and lithium response in the treatment of bipolar disorder.Genes, brain, and behavior · 2011Article
- Polymorphisms in melatonin synthesis pathways: possible influences on depression.Journal of circadian rhythms · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundBased on results from randomized, controlled clinical trials, lithium monotherapy or lithium with the addition of an antipsychotic remains a first-line treatment option for both acute and long-term mood stabilization in bipolar mania. However, response to lithium is poor in bipolar patients who exhibit clinical characteristics such as rapid cycling and mixed manic states, suggesting that they may have a biologically and genetically distinct form of bipolar disorder. A test that could predict response to lithium based upon genetic factors would have significant clinical value.
methodsEight clinical characteristics were assessed in 92 lithium responders and 92 nonresponders; all probands were from families recruited for linkage studies. Lithium response was rated retrospectively from a standardized interviews and medical records. Eight candidate genes were selected from those reported to be associated with susceptibility to illness, lithium response, or lithium mechanism of action. Sixty-seven single nucleotide polymorphisms (SNPs) were genotyped in these subjects and analyzed for association with the defined clinical characteristics.
resultsUsing q-value analysis for multiplicity correction, we found significant interactions between lithium response and SNPs (rs1387923 and rs1565445) in the gene encoding neurotrophic tyrosine kinase receptor type 2 (NTRK2) and suicidal ideation, and between SNP rs2064721 in the gene encoding inositol polyphosphate-1-phosphatase (INPP1) and post-traumatic stress disorder.
conclusionThese data support the idea that response to lithium has a multi-genetic etiology dependent upon manifestations of other clinical co-diagnoses.
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Registered trials
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