ArticleMechanisms of ageing and development
Lower GrB+ CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes.
Article in Mechanisms of ageing and development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Influenza vaccine-mediated protection in older adults: Impact of influenza infection, cytomegalovirus serostatus and vaccine dosage.Experimental gerontology · 2018Trial
- Recall responses to tetanus and diphtheria vaccination are frequently insufficient in elderly persons.PloS one · 2013Trial
- The role of T cells in influenza infection and vaccination.Virologica Sinica · 2026Review
- Antibody Responsiveness to Influenza: What Drives It?Viruses · 2021Review
- Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration.Journal of cachexia, sarcopenia and muscle · 2020Article
- A PBMC-Based System to Assess Human T Cell Responses to Influenza Vaccine Candidates In Vitro.Vaccines · 2019Article
- Aging, Health, and Quality of Life for Older People Living With HIV in Sub-Saharan Africa: A Review and Proposed Conceptual Framework.Journal of aging and health · 2019Article
- Cytomegalovirus Seropositivity Predicts a Decline in the T Cell But Not the Antibody Response to Influenza in Vaccinated Older Adults Independent of Type 2 Diabetes Status.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection.Frontiers in immunology · 2017Review
- Heterosubtypic T-Cell Immunity to Influenza in Humans: Challenges for Universal T-Cell Influenza Vaccines.Frontiers in immunology · 2016Review
- Is HIV a model of accelerated or accentuated aging?The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Review
- Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans.Journal of leukocyte biology · 2013Article
- Slower immune system aging in women versus men in the Japanese population.Immunity & ageing : I & A · 2013Article
- Translational research in immune senescence: assessing the relevance of current models.Seminars in immunology · 2012Review
- Review
- Vaccination in the elderly.Microbial biotechnology · 2012Review
- Immunosenescence and Challenges of Vaccination against Influenza in the Aging Population.Aging and disease · 2012Article
- Vaccinomics and a new paradigm for the development of preventive vaccines against viral infections.Omics : a journal of integrative biology · 2011Review
- Expansions of NK-like αβT cells with chronologic aging: novel lymphocyte effectors that compensate for functional deficits of conventional NK cells and T cells.Ageing research reviews · 2011Review
- Two pathways of costimulation through CD28.Immunologic research · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Older adults who are at risk of developing influenza illness, have a low level of influenza virus-stimulated cytotoxic T lymphocyte (CTL) activity as measured by an assay of granzyme B (GrB). The purpose of this study was to determine whether aging affected memory CTL populations identified by GrB expression in influenza virus-stimulated peripheral blood mononuclear cells (PBMC). The expression and activity of GrB increased with virus stimulation over 5 days of culture. Virus-specific CD8 effector T cells with the phenotype, GrB+ CD62L(high) CD8 T(CM), were found to be the source of the early CTL response to influenza virus. Comparing the CD8 T cell response in 5-day PBMC cultures of 161 adult subjects, the response of GrB+ CD62L(high) CD8 T(CM) lymphocytes in older individuals was significantly lower than in younger adults after viral stimulation (p<0.001). The increase in the proportion of CD28(null) CD8 T cells in fresh PBMC negatively correlated with the proportion GrB+ CD62L(high) CD8 T(CM) lymphocytes in virus-stimulated PBMC. Thus, the increase in CD28(null) CD8 T cells with age may contribute to the limited CTL response to influenza vaccination and diminished protection in older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.