ReviewPituitary2007
Traumatic brain injury induced hypothalamic-pituitary dysfunction: a paediatric perspective.
Review in Pituitary, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group.Brain imaging and behavior · 2021Pooled it
- Paediatric traumatic brain injury: unique population and unique challenges.Brain : a journal of neurology · 2026Review
- Sexual Dimorphisms in Neurodevelopment May Affect TBI Recovery in Pediatric Patients.Biomedicines · 2025Review
- Previous traumatic brain injury is associated with an increased odds for gestational diabetes: a nationwide register-based cohort study in finland.Acta diabetologica · 2023Article
- Multifetal gestations after traumatic brain injury: a nationwide register-based cohort study in Finland.BMC pregnancy and childbirth · 2023Article
- Review
- Neuroimaging of the Injured Pediatric Brain: Methods and New Lessons.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- Diverging volumetric trajectories following pediatric traumatic brain injury.NeuroImage. Clinical · 2017Article
- Pituitary function in children following infectious diseases of the central nervous system.Pituitary · 2014Article
- Sociosexual and communication deficits after traumatic injury to the developing murine brain.PloS one · 2014Article
- Measurement of height velocity is an useful marker for monitoring pituitary function in patients who had traumatic brain injury.Pituitary · 2013Article
- Secondary adrenal insufficiency in the acute phase of pediatric traumatic brain injury.Intensive care medicine · 2010Article
- Evaluation of pituitary function in cases with the diagnosis of pediatric mild traumatic brain injury: Cross-sectional study.Journal of neurosciences in rural practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In survivors of traumatic brain injury (TBI), impairment in anterior pituitary hormone function may be an important cause of long-term morbidity. Histopathological evidence from post-mortem studies suggests that the hypothalamic-pituitary structures are vulnerable to damage following head injury. Pituitary dysfunction, present months or years after injury, is now well recognised in adults, however, little evidence is known about this potential complication in children and adolescents. This article reviews the available paediatric data, which shows that hypopituitarism may occur after both mild and severe TBI, with growth hormone and gonadotrophin deficiencies appearing to be most common abnormalities. Central precocious puberty has also been documented. There are, however, few published data within a population of children with TBI on the incidence or prevalence of hypopituitarism, nor on its natural history or response to hormone replacement, and prospective studies are needed. Given the critical role of anterior pituitary hormones in the regulation of growth, pubertal and neurocognitive development in childhood, early detection of hormone abnormalities following TBI is important. We propose that a multidisciplinary approach to follow-up and endocrine assessment is required for the long-term management and rehabilitation of children and adolescents who survive moderate to severe head injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.